Hemodynamic impact of a positive end-expiratory pressure setting in acute respiratory distress syndrome: importance of the volume status

E Fougères, JL Teboul, C Richard, D Osman… - Critical care …, 2010 - journals.lww.com
Objective: The hemodynamic impact of positive end-expiratory pressure in acute respiratory
distress syndrome and the underlying mechanisms have not been extensively investigated …

Pulmonary vascular dysfunction induced by high tidal volume mechanical ventilation

C Menendez, L Martinez-Caro, L Moreno… - Critical care …, 2013 - journals.lww.com
Objectives: Acute lung injury and acute respiratory distress syndrome are characterized by
increased pulmonary artery pressure and ventilation-perfusion mismatch. We analyzed the …

Lung regional metabolic activity and gas volume changes induced by tidal ventilation in patients with acute lung injury

G Bellani, L Guerra, G Musch, A Zanella… - American journal of …, 2011 - atsjournals.org
Rationale: During acute lung injury (ALI), mechanical ventilation can aggravate inflammation
by promoting alveolar distension and cyclic recruitment–derecruitment. As an estimate of the …

Prognostic value of the pulmonary dead-space fraction during the first 6 days of acute respiratory distress syndrome

RH Kallet, JA Alonso, JF Pittet, MA Matthay - Respiratory Care, 2004 - rc.rcjournal.com
BACKGROUND: The ratio of pulmonary dead space to tidal volume (VD/VT) in acute
respiratory distress syndrome (ARDS) is reported to be between 0.35 and 0.55. However …

Are low tidal volumes safe?

PC Lee, CM Helsmoortel, SM Cohn, MP Fink - Chest, 1990 - Elsevier
High airway pressure may be injurious to lung parenchyma, but lowering airway pressure
using conventional mechanical ventilation necessitates lowering tidal volume (VT) …

Effects of positive end-expiratory pressure on regional distribution of tidal volume and recruitment in adult respiratory distress syndrome.

L Gattinoni, P Pelosi, S Crotti… - American journal of …, 1995 - atsjournals.org
The distribution of tidal volume (VT) and recruitment was investigated by chest computed
tomography (CT) in eight sedated-paralyzed patients with the adult respiratory distress …

Tidal volume reduction in ARDS: effect on cardiac output and arterial oxygenation

JW Leatherman, RL Lari, C Iber, AL Ney - Chest, 1991 - Elsevier
During continuous positive pressure ventilation (CPPV), mean airway pressure and lung
volume will be influenced both by the tidal volume (VT) employed and the amount of positive …

High PEEP levels are associated with overdistension and tidal recruitment/derecruitment in ARDS patients

J Retamal, G Bugedo, A Larsson… - Acta Anaesthesiologica …, 2015 - Wiley Online Library
Background Positive end‐expiratory pressure (PEEP) improves gas exchange and
respiratory mechanics, and it may decrease tissue injury and inflammation. The mechanisms …

Ventilation with lower tidal volumes as compared with conventional tidal volumes for patients without acute lung injury: a preventive randomized controlled trial

RM Determann, A Royakkers, EK Wolthuis, AP Vlaar… - Critical care, 2010 - Springer
Introduction Recent cohort studies have identified the use of large tidal volumes as a major
risk factor for development of lung injury in mechanically ventilated patients without acute …

Tidal volume and plateau pressure use for acute lung injury from 2000 to present: a systematic literature review

DS Jaswal, JM Leung, J Sun, X Cui, Y Li… - Critical care …, 2014 - journals.lww.com
Objective: Since publication of the Respiratory Management of Acute Lung Injury and Acute
Respiratory Distress Syndrome (ARMA) trial in 2000, use of tidal volume (VT) less than or …