Genetic variation between diverse mouse species is well-characterized, yet existing
knowledge of the mouse transcriptome comes largely from one mouse strain (C57BL/6J). As …

Study of microbial genomes has provided new insight into the functions that pathogens
require for survival in the animal host. Small genome bacterial pathogens, defined as …

A century ago, Gertrude Stein told us that a rose is a rose is a rose, but today, modern
genomics is telling us that a pathogen is not a pathogen. Advances in pathogenomics have …

Humans are infected with a variety of acute and chronic pathogens over the course of their
lives, and pathogen-driven selection has shaped the immune system of humans. The same …

Five years into the human postgenomic era, we are gaining considerable knowledge about
host-pathogen interactions through host genomes. This" infectogenomics" approach should …

It can be argued that the arrival of the “genomics era” has significantly shifted the paradigm
of vaccine and therapeutics development from microbiological to sequence-based …

The central paradigm of vaccination is to generate resistance to infection by a specific
pathogen when the vacinee is re-exposed to that pathogen. This paradigm is based on two …

Survival during an epidemic is partly determined by host genetics. While quantitative genetic
studies typically consider survival as an indicator for disease resistance (an individual's …

Background The use of inbred mice housed under standardized environmental conditions
has been critical in identifying immuno-pathological mechanisms in different infectious and …

Infectious diseases are a leading cause of morbidity and mortality worldwide, and vaccines
are one of the most successful and cost-effective tools for disease prevention. One of the key …