Background Optimising the use of antimicrobials is a key priority of the global strategy to
combat antimicrobial resistance (AMR). 1 Antibiotic guidance should be developed to meet …

Comment www. thelancet. com/infection Vol 19 December 2019 1279 of activity, and
potential for inducing antimicrobial resistance, whereas Reserve antibiotics were selected …

Comment www. thelancet. com/infection Vol 22 November 2022 1529 stewardship,
particularly optimising the use of Access antibiotics and short durations when appropriate …

Antibiotic use not only underpins modern medicine, but has brought huge changes to the
world, especially in expectations of survival of children into adulthood. The theme of World …

Summary Background The WHO Model List of Essential Medicines classified antibiotics into
Access, Watch, and Reserve (AWaRe) categories for the treatment of 31 priority bacterial …

In February, 2016, WHO released a report for the development of national action plans to
address the threat of antibiotic resistance, the catastrophic consequences of inaction, and …

Worldwide, antimicrobial resistance is increasing at an alarming rate. In 2019, WHO listed
antimicrobial resistance as one of the top ten threats to global health. 1 A major driver of …

Global access to effective antimicrobials is under threat. 1 Over 700 000 deaths worldwide,
including 214 000 neonatal sepsis deaths, are attributable to resistant bacterial pathogens …

In 1945, Sir Alexander Fleming famously warned of the danger of over-reliance on
antibiotics and the threat of bacteria developing resistance. 1 68 years later, his prediction …

To bring new antibacterial drugs to the market is challenging because discovery of new
agents is difficult, two large trials per indication are needed in accordance with traditional …