During nervous system development, spinal commissural axons project toward floor plate
cells and trochlear motor axons extend away from these cells. Netrin-1, a diffusible protein …

Netrin1 has been proposed to act from the floor plate (FP) as a long-range diffusible
chemoattractant for commissural axons in the embryonic spinal cord. However, netrin1 …

Netrin-1 is an evolutionarily conserved, secreted extracellular matrix protein involved in
axon guidance at the central nervous system midline,. Netrin-1 is expressed by cells …

In vertebrates, commissural axons extend ventrally toward the floor plate in the spinal cord
and hindbrain. Netrin-1, secreted by floor plate cells, was proposed to attract commissural …

An important model for axon pathfinding is provided by guidance of embryonic commissural
axons from dorsal spinal cord to ventral midline floor plate (FP). FP cells produce a …

Proper patterning of the nervous system requires that developing axons find appropriate
postsynaptic partners; this entails microns to meters of extension through an extracellular …

During nervous system development, spinal commissural axons project toward and across
the ventral midline. They are guided in part by netrin-1, made by midline cells, which attracts …

An intermediate target for axons leaving the cerebral cortex in embryonic mammals is the
ganglionic eminence (GE), the embryonic precursor of the basal ganglia. The cues that …

Gradients of diffusible long-range attractant and repellent proteins have been proposed to
guide growing axons during nervous system development, but such gradients have never …

Dorsal root ganglion (DRG) neurons extend axons to specific targets in the gray matter of the
spinal cord. During development, DRG axons grow into the dorsolateral margin of the spinal …