Type III IFNs, or IFN-λ, are the newest members of the IFN family and were long believed to
play roles that were redundant with those of type I IFNs. However, IFN-λ displays unique …

Type III interferons (IFNs)(or IFN-λ) are the latest addition to the IFN family. Even though they
share little protein homology with type I IFN, both exhibit remarkable functional similarities …

Virus-infected cells secrete a broad range of interferons (IFN) which confer resistance to yet
uninfected cells by triggering the synthesis of antiviral factors. The relative contributions of …

The unexpected discovery of a novel family of antiviral mediators, type III IFNs or IFN-λs,
challenged the widely accepted primacy of type I IFNs in antiviral immunity, and it is now …

Type I interferons (IFN-α/β) and the more recently identified type III IFNs (IFN-λ) function as
the first line of defense against virus infection and regulate the development of both innate …

Type III interferons (IFNs) or IFN-λs regulate a similar set of genes as type I IFNs, but
whereas type I IFNs act globally, IFN-λs primarily target mucosal epithelial cells and protect …

Highlights•Type III interferons are antiviral factors that are expressed in response to
numerous viral infections.•Type III interferons are most crucial for controlling viral infections …

Interferon (IFN)-λ forms the type III IFN family. Although they signal through distinct receptors,
type I (IFN-α/β) and type III IFNs elicit remarkably similar responses in cells. However, in …

Interferons (IFNs) constitute the first line of defense against microbial infections particularly
against viruses. They provide antiviral properties to cells by inducing the expression of …

Type I interferons (IFNs) are a family of cytokines specialized to coordinate immunity to
viruses and other intracellular infections. In the past several years, many of the receptors …