[HTML][HTML] Before the beginning: environmental exposures and reproductive and obstetrical outcomes

TR Segal, LC Giudice - Fertility and sterility, 2019 - Elsevier
There is growing consensus that preconception exposure to environmental toxins can
adversely affect fertility, pregnancy, and fetal development, which may persist into the …

Environmental factors in declining human fertility

NE Skakkebæk, R Lindahl-Jacobsen… - Nature Reviews …, 2022 - nature.com
A severe decline in child births has occurred over the past half century, which will lead to
considerable population declines, particularly in industrialized regions. A crucial question is …

The role of polycystic ovary syndrome in reproductive and metabolic health: overview and approaches for treatment

CC Dennett, J Simon - Diabetes Spectrum, 2015 - Am Diabetes Assoc
(SHBG)(13). Reduced SHBG levels lead to an increase in free testosterone levels (14).
Women with PCOS who have chronic anovulation but normal androgen levels tend to not be …

The epigenetic impacts of endocrine disruptors on female reproduction across generations

S Rattan, JA Flaws - Biology of reproduction, 2019 - academic.oup.com
Humans and animals are repeatedly exposed to endocrine disruptors, many of which are
ubiquitous in the environment. Endocrine disruptors interfere with hormone action; thus …

[HTML][HTML] Proceedings of the summit on environmental challenges to reproductive health and fertility: executive summary

TJ Woodruff, A Carlson, JM Schwartz, LC Giudice - Fertility and sterility, 2008 - Elsevier
The 2007 Summit on Environmental Challenges to Reproductive Health and Fertility
convened scientists, health care professionals, community groups, political representatives …

Environmentally induced epigenetic transgenerational inheritance of ovarian disease

E Nilsson, G Larsen, M Manikkam… - PloS one, 2012 - journals.plos.org
The actions of environmental toxicants and relevant mixtures in promoting the epigenetic
transgenerational inheritance of ovarian disease was investigated with the use of a …

Epigenetic transgenerational actions of endocrine disruptors

MK Skinner, M Manikkam, C Guerrero-Bosagna - Reproductive toxicology, 2011 - Elsevier
Environmental factors have a significant impact on biology. Therefore, environmental
toxicants through similar mechanisms can modulate biological systems to influence …

Hyperandrogenic origins of polycystic ovary syndrome–implications for pathophysiology and therapy

DH Abbott, DA Dumesic, JE Levine - Expert review of …, 2019 - Taylor & Francis
Introduction: Polycystic ovary syndrome (PCOS) diagnosis comprises combinations of
female hyperandrogenism, menstrual irregularity and polycystic ovaries. While it is a familial …

The development of the polycystic ovary syndrome: family history as a risk factor

M Kahsar-Miller, R Azziz - Trends in Endocrinology & Metabolism, 1998 - cell.com
Three general genetic models for the development of the polycystic ovary syndrome (PCOS)
can be proposed, namely:(1) the" single-gene Mendelian" model, which considers the …

[HTML][HTML] Endocrine disruptors, environmental oxygen, epigenetics and pregnancy

JC Robins, CJ Marsit, JF Padbury… - Frontiers in bioscience …, 2011 - ncbi.nlm.nih.gov
The placenta and its myriad functions are central to successful reproductive outcomes.
These functions can be influenced by the environment encountered throughout pregnancy …