Phosphine-gold (I) compounds as anticancer agents: general description and mechanisms of action

J Carlos Lima, L Rodriguez - Anti-Cancer Agents in Medicinal …, 2011 - ingentaconnect.com
Gold complexes have been explored as metallodrugs with great potential applications as
antitumoral agents. In particular, gold-phosphine derivatives seemed quite promising since …

On the medicinal chemistry of gold complexes as anticancer drugs

I Ott - Coordination Chemistry Reviews, 2009 - Elsevier
Metal complexes have shown interesting preclinical and clinical results as antitumor drugs
and platinum compounds are well established in current cancer chemotherapy. However …

A new target for gold (I) compounds: glutathione-S-transferase inhibition by auranofin

A De Luca, CG Hartinger, PJ Dyson, ML Bello… - Journal of Inorganic …, 2013 - Elsevier
Nowadays, gold compounds occupy a relevant position constituting a promising class of
experimental anticancer metallodrugs. Several research efforts have been devoted to the …

Mechanisms of cytotoxicity and antitumor activity of gold (I) phosphine complexes: the possible role of mitochondria

MJ McKeage, L Maharaj, SJ Berners-Price - Coordination Chemistry …, 2002 - Elsevier
Well known for their clinical anti-arthritic properties, gold-based drugs have also attracted
interest as potential antitumor agents with gold (I) phosphine derivatives being among the …

Antitumor activity of the mixed phosphine gold species chlorotriphenylphosphine-1, 3-bis (diphenylphosphino) propanegold (I)

F Caruso, M Rossi, J Tanski, C Pettinari… - Journal of medicinal …, 2003 - ACS Publications
The title compound has been designed for antitumor activity based on structural features of
related known antitumor gold agents, that is, gold-monophosphine and gold-diphosphine …

Synthesis, properties, and antitumor effects of a new mixed phosphine gold (I) compound in human colon cancer cells

G Lupidi, L Avenali, M Bramucci, L Quassinti… - Journal of Inorganic …, 2013 - Elsevier
The antineoplastic potential of a new stable mixed phosphine gold (I) complex containing
tris (tert-butyl) phosphine (tBu3P) and bis (diphenylphosphino) ethene (dppet), namely [Au …

Anticancer agents: does a phosphonium behave like a gold (I) phosphine complex? Let a “smart” probe answer!

M Ali, L Dondaine, A Adolle, C Sampaio… - Journal of Medicinal …, 2015 - ACS Publications
Gold phosphine complexes, such as auranofin, have been recognized for decades as
antirheumatic agents. Clinical trials are now underway to validate their use in anticancer or …

Advances in diphosphine ligand-containing gold complexes as anticancer agents

N Mirzadeh, TS Reddy, SK Bhargava - Coordination Chemistry Reviews, 2019 - Elsevier
The last decade has witnessed tremendous advances in the design of anticancer gold
complexes containing tertiary phosphines, a class of ligands that have significantly …

Anti-cancer gold (I) phosphine complexes: Cyclic trimers and tetramers containing the P-Au-P moiety

TS Reddy, SH Privér, N Mirzadeh… - Journal of Inorganic …, 2017 - Elsevier
We report the application of cationic tri-and tetra-nuclear gold (I) phosphine complexes [Au 3
(μ-dppen) 3] X 3 and [Au 4 (μ-dppa) 4] X 4 (X= OTf, PF 6)[OTf= trifluoromethanesulfonate …

Naphthalimide gold (I) phosphine complexes as anticancer metallodrugs

CP Bagowski, Y You, H Scheffler, DH Vlecken… - Dalton …, 2009 - pubs.rsc.org
Gold (I) phosphine complexes exhibit promising properties for anticancer drug development.
Here we report on a series of gold (I) phosphine complexes containing a naphthalimide …