[HTML][HTML] 5-Aminoisoquinolinone, a PARP-1 inhibitor, ameliorates immune abnormalities through upregulation of anti-inflammatory and downregulation of inflammatory …

K Alhosaini, MA Ansari, A Nadeem, SA Bakheet… - Brain Sciences, 2021 - mdpi.com
Autism spectrum disorder (ASD) covers a range of neurodevelopmental disorders involving
impairments in communication and repetitive and stereotyped patterns of behavior and …

5-aminoisoquinolinone attenuates social behavior deficits and immune abnormalities in the BTBR T+ Itpr3tf/J mouse model for autism

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Pharmacology …, 2020 - Elsevier
Autism spectrum disorder (ASD) is diagnosed by core symptoms including impaired social
communication and the presence of repetitive and stereotypical behaviors. There is also …

Protection by tyrosine kinase inhibitor, tyrphostin AG126, through the suppression of IL-17A, RORγt, and T-bet signaling, in the BTBR mouse model of autism

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Brain Research …, 2018 - Elsevier
Autism spectrum disorder (ASD) is an extremely predominant neurodevelopmental disorder
expressed as impairment in reciprocal social interaction along with repetitive, restricted, and …

[HTML][HTML] Thymol improves autism-like behaviour in VPA-induced ASD rats through the Pin1/p38 MAPK pathway

Y Xiong, J Chen, M Lv, F Wang, H Zhang… - International …, 2023 - Elsevier
Inflammation plays an essential role in the pathogenesis of autism spectrum disorder (ASD).
Thymol is a bioactive monoterpene isolated from Thymus vulgaris that has anti-inflammatory …

Toll-like receptors, NF-κB, and IL-27 mediate adenosine A2A receptor signaling in BTBR T+ Itpr3tf/J mice

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Progress in Neuro …, 2017 - Elsevier
Autism is a predominant neurodevelopmental disorder characterized by impaired
communication, social deficits, and repetitive behaviors. Recent research has proposed that …

Adenosine A2A receptor signaling affects IL-21/IL-22 cytokines and GATA3/T-bet transcription factor expression in CD4+ T cells from a BTBR T+ Itpr3tf/J mouse model …

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Journal of …, 2017 - Elsevier
Autism is a complex heterogeneous neurodevelopmental disorder; previous studies have
identified altered immune responses among individuals diagnosed with autism. An …

The PPARδ agonist GW0742 restores neuroimmune function by regulating Tim-3 and Th17/Treg-related signaling in the BTBR autistic mouse model

SF Ahmad, A Nadeem, MA Ansari, SA Bakheet… - Neurochemistry …, 2018 - Elsevier
Autism spectrum disorders (ASD) are neurodevelopmental disorders that are characterized
by repetitive behaviors, and impairments in communication and social interaction. Studies …

[HTML][HTML] Humulus japonicus rescues autistic‑like behaviours in the BTBR T+ Itpr3tf/J mouse model of autism

HY Park, J Go, YK Ryu, DH Choi… - Molecular …, 2021 - spandidos-publications.com
Humulus japonicus (HJ) is a traditional herbal medicine that exhibits anti‑inflammatory,
antimicrobial and anti‑tumor effects that is used for the treatment of hypertension, pulmonary …

PI3K/AKT/mTOR signalling inhibitor chrysophanol ameliorates neurobehavioural and neurochemical defects in propionic acid-induced experimental model of autism …

A Sharma, S Bhalla, S Mehan - Metabolic brain disease, 2022 - Springer
Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder marked by
social and communication deficits as well as repetitive behaviour. Several studies have …

Inhibition of tyrosine kinase signaling by tyrphostin AG126 downregulates the IL-21/IL-21R and JAK/STAT pathway in the BTBR mouse model of autism

SF Ahmad, MA Ansari, A Nadeem, SA Bakheet… - Neurotoxicology, 2020 - Elsevier
Autism spectrum disorder (ASD) comprises a broad range of neurodevelopmental disorders
that are associated with deficits in social interaction and communication. The tyrosine kinase …