To further explore whether immune function and acute phase response are altered during
ageing, the response to a mild inflammatory stress (DT-Polio-Typhim vaccination) was …

Periodontitis is one of the most prevalent infectious inflammatory diseases, characterized by
irreversible destruction of the supporting tissues of teeth, which is correlated with a greater …

A well-established feature of physiological ageing is altered immune function, a
phenomenon termed immunesenescence. Thought to be responsible in part for the …

In the older adult, the benefits of vaccination to prevent infectious disease are limited, mainly
because of the adaptive immune system's inability to generate protective immunity. The age …

As we age, it is common for certain phenotypic changes to arise within the population. A
number of observations have led scientists to believe that these changes result from an …

Host defense against bacterial and fungal infections diminishes with age. In humans,
impaired neutrophil responses are thought to contribute to this decline. However, it remains …

The decline in immunity in the elderly has largely been attributed to impairment of T cell
mechanisms. This seems reasonable since the thymus involutes with age, so that the …

The function of the immune system declines during aging, compromising its response
against pathogens, a phenomenon termed as “immunosenescence.” Alterations of the …

Aging is accompanied by many physiological changes including those in the immune
system. These changes are designated as immunosenescence indicating that age induces …

Major advances in preventing, delaying, or curing individual pathologies are responsible for
an increasingly long life span in the developed parts of our planet, and indeed reaching …