[HTML][HTML] Targeting NLRP3 inflammasome modulates gut microbiota, attenuates corticospinal tract injury and ameliorates neurobehavioral deficits after intracerebral …
L Xiao, H Zheng, J Li, M Zeng, D He, J Liang… - Biomedicine & …, 2022 - Elsevier
Intracerebral hemorrhage (ICH) has a high mortality and disability rate. Fewer studies focus
on white matter injury (WMI) after ICH, especially the corticospinal tract (CST) injury located …
on white matter injury (WMI) after ICH, especially the corticospinal tract (CST) injury located …
Interplay between gut microbiota and NLRP3 inflammasome in intracerebral hemorrhage
Y Zhang, W Yu, C Flynn, W Chang, L Zhang, M Wang… - Nutrients, 2022 - mdpi.com
The pathophysiological process of intracerebral hemorrhage (ICH) is very complex,
involving various mechanisms such as apoptosis, oxidative stress and inflammation. As one …
involving various mechanisms such as apoptosis, oxidative stress and inflammation. As one …
NLRP3 inflammasome contributes to inflammation after intracerebral hemorrhage
Objective The NLRP3 (NALP3, cryopyrin) inflammasome, a key component of the innate
immune system, facilitates caspase‐1 and interleukin (IL)− 1β processing, which amplifies …
immune system, facilitates caspase‐1 and interleukin (IL)− 1β processing, which amplifies …
[HTML][HTML] Secondary white matter injury mediated by neuroinflammation after intracerebral hemorrhage and promising therapeutic strategies of targeting the NLRP3 …
L Xiao, M Wang, Y Shi, Y Xu, Y Gao… - Current …, 2023 - ncbi.nlm.nih.gov
Intracerebral hemorrhage (ICH) is a neurological disease with high mortality and disability.
Recent studies showed that white matter injury (WMI) plays an important role in motor …
Recent studies showed that white matter injury (WMI) plays an important role in motor …
Selective NLRP3 (pyrin domain–containing protein 3) inflammasome inhibitor reduces brain injury after intracerebral hemorrhage
H Ren, Y Kong, Z Liu, D Zang, X Yang, K Wood, M Li… - Stroke, 2018 - Am Heart Assoc
Background and Purpose—Intracerebral hemorrhage (ICH) is a devastating disease without
effective treatment. As a key component of the innate immune system, the NOD-like receptor …
effective treatment. As a key component of the innate immune system, the NOD-like receptor …
Selective NLRP3 inflammasome inhibitor reduces neuroinflammation and improves long-term neurological outcomes in a murine model of traumatic brain injury
The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …
MCC950, a selective inhibitor of NLRP3 inflammasome, reduces the inflammatory response and improves neurological outcomes in mice model of spinal cord injury
J Jiao, G Zhao, Y Wang, P Ren, M Wu - Frontiers in molecular …, 2020 - frontiersin.org
Spinal cord injury (SCI) is a serious condition that affects bodily function; however, there is
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …
Neuroinflammation mediated by NLRP3 inflammasome after intracerebral hemorrhage and potential therapeutic targets
L Xiao, H Zheng, J Li, Q Wang, H Sun - Molecular Neurobiology, 2020 - Springer
Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of
effective treatment. Microglia are a major component of the innate immune system, and they …
effective treatment. Microglia are a major component of the innate immune system, and they …
Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice
W Jiang, M Li, F He, S Zhou, L Zhu - Journal of neuroinflammation, 2017 - Springer
Background Spinal cord injury (SCI) is a devastating disease, which results in tissue loss
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …
Lack of the Nlrp3 inflammasome improves mice recovery following traumatic brain injury
N Irrera, G Pizzino, M Calò, G Pallio… - Frontiers in …, 2017 - frontiersin.org
Treatment for traumatic brain injury (TBI) remains elusive despite compelling evidence from
animal models for a variety of therapeutic targets. The activation of the NLRP3 (Nucleotide …
animal models for a variety of therapeutic targets. The activation of the NLRP3 (Nucleotide …
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