Intracerebral hemorrhage (ICH) has a high mortality and disability rate. Fewer studies focus
on white matter injury (WMI) after ICH, especially the corticospinal tract (CST) injury located …

The pathophysiological process of intracerebral hemorrhage (ICH) is very complex,
involving various mechanisms such as apoptosis, oxidative stress and inflammation. As one …

Objective The NLRP3 (NALP3, cryopyrin) inflammasome, a key component of the innate
immune system, facilitates caspase‐1 and interleukin (IL)− 1β processing, which amplifies …

Intracerebral hemorrhage (ICH) is a neurological disease with high mortality and disability.
Recent studies showed that white matter injury (WMI) plays an important role in motor …

Background and Purpose—Intracerebral hemorrhage (ICH) is a devastating disease without
effective treatment. As a key component of the innate immune system, the NOD-like receptor …

The nucleotide-binding oligomerization domain (NOD)-like receptor family pyrin domain
containing 3 (NLRP3) inflammasome-mediated inflammatory response has emerged as a …

Spinal cord injury (SCI) is a serious condition that affects bodily function; however, there is
no effective therapy in clinical practice. MCC950, a selective NOD-like receptor protein-3 …

Intracerebral hemorrhage (ICH) is the most fatal subtype of stroke; there is still a lack of
effective treatment. Microglia are a major component of the innate immune system, and they …

Background Spinal cord injury (SCI) is a devastating disease, which results in tissue loss
and neurologic dysfunction. NLRP3 inflammasome plays an important role in the …

Treatment for traumatic brain injury (TBI) remains elusive despite compelling evidence from
animal models for a variety of therapeutic targets. The activation of the NLRP3 (Nucleotide …