Several studies have shown a role for interleukin-1 gene cluster polymorphisms in the risk
assessment for periodontal diseases. In the Study of Health in Pomerania (SHIP), 3148 …

Background: Polymorphisms within the interleukin‐1 cluster are known to be associated with
adult periodontal disease. However, interactions of genetic with other risk factors, especially …

Background: Several studies have investigated genetic polymorphisms for cytokines as
potential genetic markers for periodontitis. Some studies have found that interleukin (IL)‐1A …

Background: Genetic polymorphisms for interleukin (IL)‐1α and‐1β have been proposed as
potential genetic markers for periodontal diseases. Since the prevalence of these …

Although specific bacteria, dental plaque, and age are associated with periodontal disease,
there are currently no reliable predictors of periodontitis severity. Studies in twins have …

Background: Cross‐sectional studies have demonstrated that a specific polymorphism
(allele 2 of both IL‐1A+ 4845 and IL‐1B+ 3954) in the IL‐1 gene cluster has been …

Periodontitis is considered to be a multifactorial disease. Studies have indicated that part of
the clinical variability in periodontitis may be explained by genetic factors. Genes can affect …

Background: Periodontitis is a bacterial inflammatory disease leading to attachment loss
with the consequence of tooth loss. There exists a multifactorial risk pattern including …

Background: Periodontitis is a bacterial disease modified by multiple risk factors. The pro‐
inflammatory cytokine interleukin‐1 (IL‐1) is a key regulator of the host responses to …

This paper presents the current knowledge concerning the role of polymorphisms of IL1A
and IL1B genes in periodontitis. Attention has been paid to the role of IL-1 in the …