Cancer involves defects in the mechanisms underlying cell proliferation, death and
migration. Calcium ions are central to these phenomena, serving as major signalling agents …

Ca 2+ ions are key second messengers in both excitable and non-excitable cells. Owing to
the rather pleiotropic nature of Ca 2+ transporters and other Ca 2+-binding proteins …

Ca2+ is a ubiquitous cellular signal. Altered expression of specific Ca2+ channels and
pumps are characterizing features of some cancers. The ability of Ca2+ to regulate both cell …

Abstract Intracellular calcium (Ca2+) signals are key regulators of multiple cellular functions,
both healthy and physiopathological. It is therefore unsurprising that several cancers present …

Calcium ion (Ca2+) signaling is critical to many physiological processes, and its kinetics and
subcellular localization are tightly regulated in all cell types. All Ca2+ flux perturbations …

Cancer is caused by defects in the mechanisms underlying cell proliferation and cell death.
Calcium ions are central to both phenomena, serving as major signalling agents with spatial …

Highlights•Altered Ca 2+ homeostasis is a hallmark of cancer cells.•Deregulation of cytosolic
[Ca 2+] is implicated in metastasis and apoptosis-resistance.•Genes involved in cancer …

The remodeling of Ca2+ homeostasis has been implicated as a critical event in driving
malignant phenotypes, such as tumor cell proliferation, motility, and metastasis. Store …

It is the nature of the calcium signal, as determined by the coordinated activity of a suite of
calcium channels, pumps, exchangers and binding proteins that ultimately guides a cell's …

Increases in intracellular free Ca 2+ play a major role in many cellular processes. The
deregulation of Ca 2+ signaling is a feature of a variety of diseases, and modulators of Ca …