Structure, function, and genetics of lipoprotein (a)

K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …

Genome-wide characterization of a highly penetrant form of hyperlipoprotein (a) emia associated with genetically elevated cardiovascular risk

S Coassin, K Chemello, I Khantalin… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Lp (a)(lipoprotein [a]) is a highly atherogenic lipoprotein strongly associated
with coronary artery disease (CAD). Lp (a) concentrations are chiefly determined genetically …

Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study

J Li, LA Lange, J Sabourin, Q Duan, W Valdar… - Journal of human …, 2015 - nature.com
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …

Lipoprotein (a) in homozygous familial hypercholesterolemia

HG Kraft, A Lingenhel, FJ Raal… - … , and vascular biology, 2000 - Am Heart Assoc
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait that in the general population is largely
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …

The apolipoprotein (a) gene: linkage disequilibria at three loci differs in African Americans and Caucasians

J Rubin, HJ Kim, TA Pearson, S Holleran, L Berglund… - Atherosclerosis, 2008 - Elsevier
Lipoprotein (a)(Lp (a)) is an independent, genetically regulated cardiovascular risk factor. Lp
(a) plasma levels are largely determined by the apolipoprotein (a)(apo (a)) component, and …

Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein (a) level elevation in African Americans compared with European …

JP Chretien, J Coresh, Y Berthier-Schaad… - Journal of medical …, 2006 - jmg.bmj.com
Background: The extent which universally common or population-specific alleles can
explain between-population variations in phenotypes is unknown. The heritable coronary …

[PDF][PDF] The effect of genetic determinants of low density lipoprotein levels on lipoprotein (a)

PN Hopkins, RR Williams - Clin Invest Med, 1991 - researchgate.net
Abstract Levels of Lipoprotein (a)[Lp (a)] correlate directly with atherosclerosis risk. The Lp
(a) particle is physically and chemically similar to low density lipoprotein (LDL), the main …

Lipoprotein (a): the common, likely causal, yet elusive risk factor for cardiovascular disease1

PR Kamstrup - Journal of Lipid Research, 2017 - ASBMB
In additional analyses using data retrieved from the CARDIoGRAMplusC4D consortium,
seven of the identified SNPs in the LPA gene region were found to be significantly …

Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …

G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …

Lp (a) concentrations are related to plasma lipid concentrations

DL Rainwater - Atherosclerosis, 1996 - Elsevier
Lp (a) concentrations are controlled primarily by genetic variation at LPA, the locus encoding
the unique protein apo (a). However, the high heritability is in part a consequence of nearly …