Structure, function, and genetics of lipoprotein (a)
K Schmidt, A Noureen, F Kronenberg… - Journal of lipid …, 2016 - ASBMB
Lipoprotein (a)[Lp (a)] has attracted the interest of researchers and physicians due to its
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …
intriguing properties, including an intragenic multiallelic copy number variation in the LPA …
Genome-wide characterization of a highly penetrant form of hyperlipoprotein (a) emia associated with genetically elevated cardiovascular risk
S Coassin, K Chemello, I Khantalin… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Lp (a)(lipoprotein [a]) is a highly atherogenic lipoprotein strongly associated
with coronary artery disease (CAD). Lp (a) concentrations are chiefly determined genetically …
with coronary artery disease (CAD). Lp (a) concentrations are chiefly determined genetically …
Genome-and exome-wide association study of serum lipoprotein (a) in the Jackson Heart Study
Abstract Lipoprotein (a)(Lp (a)) is an independent risk factor for cardiovascular disease. Lp
(a) levels in African Americans (AAs) are much higher compared with that in European …
(a) levels in African Americans (AAs) are much higher compared with that in European …
Lipoprotein (a) in homozygous familial hypercholesterolemia
HG Kraft, A Lingenhel, FJ Raal… - … , and vascular biology, 2000 - Am Heart Assoc
Lipoprotein (a)[Lp (a)] is a quantitative genetic trait that in the general population is largely
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …
controlled by 1 major locus—the locus for the apolipoprotein (a)[apo (a)] gene. Sibpair …
The apolipoprotein (a) gene: linkage disequilibria at three loci differs in African Americans and Caucasians
J Rubin, HJ Kim, TA Pearson, S Holleran, L Berglund… - Atherosclerosis, 2008 - Elsevier
Lipoprotein (a)(Lp (a)) is an independent, genetically regulated cardiovascular risk factor. Lp
(a) plasma levels are largely determined by the apolipoprotein (a)(apo (a)) component, and …
(a) plasma levels are largely determined by the apolipoprotein (a)(apo (a)) component, and …
Three single-nucleotide polymorphisms in LPA account for most of the increase in lipoprotein (a) level elevation in African Americans compared with European …
JP Chretien, J Coresh, Y Berthier-Schaad… - Journal of medical …, 2006 - jmg.bmj.com
Background: The extent which universally common or population-specific alleles can
explain between-population variations in phenotypes is unknown. The heritable coronary …
explain between-population variations in phenotypes is unknown. The heritable coronary …
[PDF][PDF] The effect of genetic determinants of low density lipoprotein levels on lipoprotein (a)
PN Hopkins, RR Williams - Clin Invest Med, 1991 - researchgate.net
Abstract Levels of Lipoprotein (a)[Lp (a)] correlate directly with atherosclerosis risk. The Lp
(a) particle is physically and chemically similar to low density lipoprotein (LDL), the main …
(a) particle is physically and chemically similar to low density lipoprotein (LDL), the main …
Lipoprotein (a): the common, likely causal, yet elusive risk factor for cardiovascular disease1
PR Kamstrup - Journal of Lipid Research, 2017 - ASBMB
In additional analyses using data retrieved from the CARDIoGRAMplusC4D consortium,
seven of the identified SNPs in the LPA gene region were found to be significantly …
seven of the identified SNPs in the LPA gene region were found to be significantly …
Lipoprotein (a): a genetically determined, causal, and prevalent risk factor for atherosclerotic cardiovascular disease: a scientific statement from the American Heart …
G Reyes-Soffer, HN Ginsberg, L Berglund… - … , and vascular biology, 2022 - Am Heart Assoc
High levels of lipoprotein (a)[Lp (a)], an apoB100-containing lipoprotein, are an independent
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …
and causal risk factor for atherosclerotic cardiovascular diseases through mechanisms …
Lp (a) concentrations are related to plasma lipid concentrations
DL Rainwater - Atherosclerosis, 1996 - Elsevier
Lp (a) concentrations are controlled primarily by genetic variation at LPA, the locus encoding
the unique protein apo (a). However, the high heritability is in part a consequence of nearly …
the unique protein apo (a). However, the high heritability is in part a consequence of nearly …