Hyperlipidemia and cardiovascular disease: new insights on lipoprotein (a)
R Burkhardt - Current opinion in lipidology, 2019 - journals.lww.com
Elevated plasma level of LDL-cholesterol (LDL-C) is a modifiable major risk factor for
atherosclerotic cardiovascular disease. Several LDL-C-lowering agents successfully reduce …
atherosclerotic cardiovascular disease. Several LDL-C-lowering agents successfully reduce …
Genome-wide linkage analysis for identifying quantitative trait loci involved in the regulation of lipoprotein a (Lpa) levels
Lipoprotein Lp (a) levels are highly heritable and are associated with cardiovascular risk.
We performed a genome-wide linkage analysis to delineate the genomic regions that …
We performed a genome-wide linkage analysis to delineate the genomic regions that …
Apolipoprotein (a) genetic sequence variants associated with systemic atherosclerosis and coronary atherosclerotic burden but not with venous thromboembolism
A Helgadottir, S Gretarsdottir, G Thorleifsson… - Journal of the American …, 2012 - jacc.org
Objectives: The purpose of this study is investigate the effects of variants in the
apolipoprotein (a) gene (LPA) on vascular diseases with different atherosclerotic and …
apolipoprotein (a) gene (LPA) on vascular diseases with different atherosclerotic and …
A comprehensive map of single-base polymorphisms in the hypervariable LPA kringle IV type 2 copy number variation region [S]
Lipoprotein (a)[Lp (a)] concentrations are among the strongest genetic risk factors for
cardiovascular disease and present pronounced interethnic and interindividual differences …
cardiovascular disease and present pronounced interethnic and interindividual differences …
Coronary artery disease and the risk-associated LPA variants, rs3798220 and rs10455872, in patients with suspected familial hypercholesterolaemia
Background The rs3798220 and rs10455872 single nucleotide polymorphisms (SNPs) in
LPA are associated with increased plasma concentrations of lipoprotein (a)[Lp (a)] and …
LPA are associated with increased plasma concentrations of lipoprotein (a)[Lp (a)] and …
High degree of genetic polymorphism in apolipoprotein (a) associated with plasma lipoprotein (a) levels in Japanese and Chinese populations
S Kikuchi, A Nakagawa, K Kobayashi, L Li, H Yanagi… - Human genetics, 1993 - Springer
We have developed a sensitve, high-resolution method for the analysis of the apolipoprotein
(a)[apo (a)] isoforms using sodium dodecyl sulfate (SDS)-agarose/gradient polyacrylamide …
(a)[apo (a)] isoforms using sodium dodecyl sulfate (SDS)-agarose/gradient polyacrylamide …
Lipoprotein (a) levels in familial hypercholesterolemia: an important predictor of cardiovascular disease independent of the type of LDL receptor mutation
R Alonso, E Andres, N Mata, F Fuentes-Jiménez… - Journal of the American …, 2014 - jacc.org
Objectives: The aim of this study was to determine the relationship between lipoprotein
(a)[Lp (a)] and cardiovascular disease (CVD) in a large cohort of patients with heterozygous …
(a)[Lp (a)] and cardiovascular disease (CVD) in a large cohort of patients with heterozygous …
Apolipoprotein (a) kringle-IV type 2 copy number variation is associated with venous thromboembolism
E Sticchi, A Magi, PR Kamstrup, R Marcucci, D Prisco… - PLoS …, 2016 - journals.plos.org
In addition to the established association between high lipoprotein (a)[Lp (a)] concentrations
and coronary artery disease, an association between Lp (a) and venous thromboembolism …
and coronary artery disease, an association between Lp (a) and venous thromboembolism …
Genetic predictor to identify individuals with high lipoprotein (a) concentrations
Recent advances in drug development aim to transi-tion lipoprotein (a)(Lp [a]) from a
predictive biomarker of cardiovascular disease to a therapeutic target. Among those with …
predictive biomarker of cardiovascular disease to a therapeutic target. Among those with …
Relation of serum lipoprotein (a) levels to lipoprotein and apolipoprotein profiles and atherosclerotic diseases in Japanese patients with heterozygous familial …
R Naito, H Daida, D Masuda… - … of Atherosclerosis and …, 2022 - jstage.jst.go.jp
Aims: Lipoprotein (a)[Lp (a)] is a plasma lipoprotein consisting of a low-density lipoprotein
(LDL)–like particle with apolipoprotein (Apo)(a), attached via a disulfide bond to Apo B100 …
(LDL)–like particle with apolipoprotein (Apo)(a), attached via a disulfide bond to Apo B100 …