Genetics of the Lp (a)/apo (a) system in an autochthonous Black African population from the Gabon
K Schmidt, HG Kraft, W Parson… - European journal of human …, 2006 - nature.com
Abstract Plasma lipoprotein (a)(Lp (a)) is a quantitative trait associated with atherothrombotic
disease in European and Asian populations. Lp (a) concentrations vary widely within and …
disease in European and Asian populations. Lp (a) concentrations vary widely within and …
Significant impact of the+ 93 C/T polymorphism in the apolipoprotein (a) gene on Lp (a) concentrations in Africans but not in Caucasians: confounding effect of linkage …
HG Kraft, M Windegger, HJ Menzel… - Human molecular …, 1998 - academic.oup.com
Abstract Lipoprotein (a)[Lp (a)] is a quantitative genetic trait in human plasma associated
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …
with atherothrombotic disease. The major determinant of Lp (a) concentration is the …
The I4399M variant of apolipoprotein (a) is associated with increased oxidized phospholipids on apolipoprotein B-100 particles
K Arai, MM Luke, ML Koschinsky, ER Miller… - Atherosclerosis, 2010 - Elsevier
OBJECTIVES: The LPA I4399M (rs3798220) single nucleotide polymorphism (SNP) is
associated with increased plasma levels of Lp (a) and advanced coronary artery disease …
associated with increased plasma levels of Lp (a) and advanced coronary artery disease …
Lipoprotein (a) is markedly more atherogenic than LDL: an apolipoprotein B-based genetic analysis
E Björnson, M Adiels, MR Taskinen, S Burgess… - Journal of the American …, 2024 - jacc.org
Abstract Background Lipoprotein (a)(Lp (a)) is recognized as a causal factor for coronary
heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on …
heart disease (CHD) but its atherogenicity relative to that of low-density lipoprotein (LDL) on …
Lipoprotein (a): impact by ethnicity and environmental and medical conditions
B Enkhmaa, E Anuurad, L Berglund - Journal of lipid research, 2016 - ASBMB
Levels of lipoprotein (a)[Lp (a)], a complex between an LDL-like lipid moiety containing one
copy of apoB, and apo (a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are …
copy of apoB, and apo (a), a plasminogen-derived carbohydrate-rich hydrophilic protein, are …
Apolipoprotein [a] genotype influences isoform dominance pattern differently in African Americans and Caucasians
J Rubin, F Paultre, CH Tuck, S Holleran, RG Reed… - Journal of lipid …, 2002 - ASBMB
Abstract Plasma lipoprotein [a](Lp [a]) concentrations are inversely associated with, and
largely determined by, apolipoprotein [a](apo [a]) gene size, a highly polymorphic trait. We …
largely determined by, apolipoprotein [a](apo [a]) gene size, a highly polymorphic trait. We …
Genetic basis and pathophysiological implications of high plasma Lp (a) levels
AM Scanu - Journal of internal medicine, 1992 - Wiley Online Library
Lipoprotein (a) or Lp (a) is a genetic variant of plasma low density lipoproteins (LDL)
containing apoB100 covalently linked to apolipoprotein (a) or apo (a), the specific marker of …
containing apoB100 covalently linked to apolipoprotein (a) or apo (a), the specific marker of …
Lipoprotein (a)—the crossroads of atherosclerosis, atherothrombosis and inflammation
S Ugovšek, M Šebeštjen - Biomolecules, 2021 - mdpi.com
Increased lipoprotein (a)(Lp (a)) levels are an independent predictor of coronary artery
disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD …
disease (CAD), degenerative aortic stenosis (DAS), and heart failure independent of CAD …
The kringle IV type 2 domain variant 4925G> A causes the elusive association signal of the LPA pentanucleotide repeat
R Grüneis, H Weissensteiner, C Lamina… - Journal of Lipid …, 2022 - ASBMB
Abstract Lipoprotein (a)[Lp (a)] concentrations are regulated by the LPA gene mainly via the
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …
large kringle IV-type 2 (KIV-2) copy number variation and multiple causal variants. Early …
Mechanisms of lipoprotein (a) pathogenicity: prothrombotic, proatherosclerotic, or both?
JD Spence, M Koschinsky - Arteriosclerosis, Thrombosis, and …, 2012 - Am Heart Assoc
(Arterioscler Thromb Vasc Biol. 2012; 32: 1550–1551.) angiographically, but carotid stenosis
(≥ 50%) was assessed by Doppler ultrasound, and peripheral vascular disease by …
(≥ 50%) was assessed by Doppler ultrasound, and peripheral vascular disease by …