Lipoprotein (a) concentrations, apolipoprotein (a) phenotypes, and peripheral arterial disease in three independent cohorts

A Laschkolnig, B Kollerits, C Lamina… - Cardiovascular …, 2014 - academic.oup.com
Aims The relevance of lipoprotein (a)[Lp (a)] concentrations and low-molecular-weight
(LMW) apo (a) phenotypes in peripheral arterial disease (PAD) has only been investigated …

Lipoprotein (a) in health and disease

F Kronenberg, A Steinmetz, GM Kostner… - Critical reviews in …, 1996 - Taylor & Francis
Abstract Lipoprotein (a)[Lp (a)] represents an LDL-like particle to which the Lp (a)-specific
apolipoprotein (a) is linked via a disulfide bridge. It has gained considerable interest as a …

[HTML][HTML] Individuals with familial hypercholesterolemia and cardiovascular events have higher circulating Lp (a) levels

C Pavanello, C Pirazzi, K Bjorkman, J Sandstedt… - Journal of Clinical …, 2019 - Elsevier
Background Cardiovascular disease (CVD) is a major cause of mortality and morbidity.
Increased low-density lipoprotein cholesterol (LDL-C) level is its major risk factor. Familial …

LPA gene: interaction between the apolipoprotein(a) size ('kringle IV' repeat) polymorphism and a pentanucleotide repeat polymorphism influences Lp(a) lipoprotein …

O Røsby, K Berg - Journal of internal medicine, 2000 - Wiley Online Library
Røsby O, Berg K (University of Oslo and Ullevål University Hospital, Oslo, Norway). LPA
gene: interaction between the apolipoprotein (a) size ('kringle IV'repeat) polymorphism and …

[HTML][HTML] Investigation of a nonsense mutation located in the complex KIV-2 copy number variation region of apolipoprotein (a) in 10,910 individuals

S Di Maio, R Grüneis, G Streiter, C Lamina… - Genome medicine, 2020 - Springer
Background The concentrations of the highly atherogenic lipoprotein (a)[Lp (a)] are mainly
genetically determined by the LPA gene locus. However, up to 70% of the coding sequence …

Sequence polymorphisms in the apo (a) gene associated with specific levels of Lp (a) in plasma

V Mooser, FP Mancini, S Bopp… - Human molecular …, 1995 - academic.oup.com
Most of the Interindividual variations in plasma levels of lipoprotein (a)[Lp (a)] can be
attributed to sequence differences linked to the apolipoprotein (a)[apo (a)] locus. Plasma …

Lipoprotein (a) and risk of myocardial infarction–genetic epidemiologic evidence of causality

PR Kamstrup, A Tybjærg-Hansen… - … journal of clinical and …, 2011 - Taylor & Francis
Elevated levels of lipoprotein (a) are associated with an increased risk of myocardial
infarction. Our study aimed to test whether genetic data are consistent with this association …

Cladistic analysis of human apolipoprotein A4 polymorphisms in relation to quantitative plasma lipid risk factors of coronary heart disease

GQ Wang, M DiPietro, K Roeder… - Annals of human …, 2003 - Wiley Online Library
Genetic variation in several genes involved in lipid metabolism is known to affect population
variation in quantitative lipid risk factor profiles for coronary heart disease (CHD). The …

Genetic factors explain a major fraction of the 50% lower lipoprotein (a) concentrations in Finns

G Erhart, C Lamina, T Lehtimäki… - … , and vascular biology, 2018 - Am Heart Assoc
Objective—Lp (a)(lipoprotein (a)) concentrations are widely genetically determined by the
LPA isoforms and show 5-fold interpopulation differences. Two-to 3-fold differences have …

Ascertainment bias in the association between elevated lipoprotein (a) and familial hypercholesterolemia

M Trinder, ML DeCastro, H Azizi, L Cermakova… - Journal of the American …, 2020 - jacc.org
Background Lipoprotein (a) is an atherogenic low-density lipoprotein–like particle and
circulating levels are largely determined by genetics. Patients with familial …