To develop antisense oligonucleotides, novel nucleosides, 2′-O, 4′-C-ethylene
nucleosides and their corresponding phosphoramidites, were synthesized as building …

2′-O-Neopentyldeoxyuridine (Un) was synthesized and incorporated into a series of
oligodeoxyribonucleotides. Single and triple incorporations in various arrangements were …

Abstract Novel nucleosides, 2′-O, 4′-C-ethylene nucleosides and their corresponding
phosphoramidites, were synthesized as building blocks for antisense oligonucleotides. The …

Abstract 3′, 4′-Ethyleneoxy-bridged 5-methyluridine derivatives with methyl groups in the
bridge,(R)-Me-3′, 4′-EoNA-T and (S)-Me-3′, 4′-EoNA-T, were synthesized, and these …

Modified oligonucleotides that contain the hydrophobic 1-hexanol-1, N6-etheno-2′-
deoxyadenosine adduct have been synthesized using a mild solid phase phosphoramidite …

In contradistinction to the corresponding Grignard reagent, bis [(trimethylsilyl) ethynyl] zinc
reacted with the 5′‐oxoadenosine 3 diastereoselectively to the β‐d‐allo‐hept‐6 …

The synthesis of oligodeoxynucleotides (ODNs) containing 5-[N-[2-[N, N-bis (2-aminoethyl)
amino] ethyl] carbamoyl]-2 '-deoxyuridine (BA E) and 5-[N-[3-[N, N-bis (3-aminopropyl) …

Abstract The synthesis of 8-methoxy-2′-deoxyadenosine (moA) protected at N6 as an N, N-
dimethylformamidine derivative and incorporation of the modified nucleoside into …

A guanylating reagent, N, N′-bis-(2-(cyano) ethoxycarbonyl)-2-thiopseudourea, was
synthesized and used for synthesis of 2′-O-[2-(guanidinium) ethyl](2′-O-GE) modified …

This chapter describes procedures for (1) the synthesis of six 2′-C, 4′-C-ethyleneoxy-
bridged thymidine phosphoramidites, ie, methylene-EoDNA-T,(R)-Me-methylene-EoDNA …