The post-synthetic modification of an oligonucleotide is a powerful strategy for the synthesis
of various analogs of the oligonucleotide, aiming to achieve the desired functions. In this …

The synthesis of oligonucleotides containing 7‐(2‐deoxy‐β‐D‐erythro‐pentofuranosyl)
guanine and 8‐amino‐2′‐deoxyguanosine was accomplished. The viable intermediate N2 …

Synthesis and properties of an oligonucleotide uniformly modified with 2′-O, 4-C-ethylene-
bridged nucleic acid (ENA) units were compared with those of GRN163, which is modified …

Oligonucleotides containing 2-substituted guanine derivatives with double-helix stabilizing
molecules such as spermine, spermidine and propylimidazole have been prepared using …

Abstract The artificial base 2‐aza‐2′‐deoxyadenosine (see figure) forms a strong and
selective purine‐purine base pair with 2′‐deoxyguanosine. As a dangling nucleotide, 2 …

The synthesis, hybridization properties and antisense activities of oligodeoxynucleotides
(ODNs) containing 7-(1-propynyl)-7-deaza-2′-deoxyguanosine (pdG) and 7-(1-propynyl)-7 …

Chloroadenosine (8-Cl-Ado) has shown potential as a chemotherapeutic agent for the
treatment of multiple myeloma and certain leukemias. 8-Cl-Ado treatment leads to a …

We synthesized thymidine derivatives of 2′-C, 4′-C-ethyleneoxy-bridged 2′-
deoxyribonucleic acids with an 8′-methyl group ((R)-Me-EoDNA and (S)-Me-EoDNA) and …

This article describes the detailed synthetic protocol for the preparation of oligonucleotides
containing 2‐guanidinoethyl‐2′‐deoxynebularine and 2‐ureidoethyl‐2 …

Glucosamino nucleic acids (GANAs) bearing a β-N-glycoside bond between carbon 1 of the
glucosamine and the nucleobase nitrogen were synthesized and incorporated into …