Synthesis of 5′-Ethynyl-2′-deoxynucleoside Analogues as Building Block for Antisense
Oligonucleotide Page 1 NUCLEOSIDES & NUCLEOTIDES, 18(6&7), 1257-1259 (1999) …

In this paper, we report a new modified base, 2-N-acetyl-3-deazaguanine (a2c3G), and the
synthesis of the 2 '-O-methyl-RNA incorporating a2c3G. It should be noted that a2c3G is the …

Incorporation of 5-propynylamino and 5-propynyl α-2′-deoxyuridine into α-oligonucleotides
(α-ON) allows high-affinity targeting of complementary DNA for α-ON with anionic and …

Abstract: 9-(2'-Deoxy-2'-C-ethynyl-bD-arabino-pentofuranosyl)-guanine phosphoramidite (8)
has been prepared from guanosine in 9 steps and incorporated into oligodeoxynucleotides …

Abstract Oligodeoxyribonucleotides containing 2′-amino-2′-deoxy-uridine (d U) were
synthesized and their ability to form duplexes with complementary DNA or RNA …

We synthesized 7-vinyl-7-deazaguanine (vzG), an N7-modified guanine base, which has a
smaller oxidation potential than G and 7-deazaG. The incorporation of vzG into …

Multiple incorporations of 7-chloro-7-deaza-2′-deoxyguanosine in place of 2′-
deoxyguanosine have been performed into a triple helix-forming oligodeoxyribonucleotide …

2′, 4′-Propylene-bridged thymidine (carba-ENA-T) and five 8′-Me/NH2/OH modified
carba-ENA-T analogues have been prepared through intramolecular radical addition to C …

The binding affinity of methyl substituted C-5 propyne and C-5 thiazole ODNs for RNA was
assessed by thermal denaturation analysis (Tm). The results indicate that increased size of …

O-Methyl-RNAs incorporating 3-deazaguanine (c3G) were synthesized by use of N, N-
diphenylcarbamoyl and N, N-dimethylaminomethylene as its base protecting groups to …