The synthesis and properties of oligonucleotides (ONs) containing 9-(2, 3, 4-trihydroxybutyl)
adenine, A C2 and A C3, are described. The ON containing A C2 involves the 3′→ 4′ and …

Oligonucleotides containing 4′-carboxy-, 4′-methoxycarbonyl-, 4′-carbamoyl-, and 4′-
methylcarbamoyl-thymidines, and their 2′-methoxy, 2′-amino or 2′-acetamido analogs …

Conformationally restricted nucleoside analogues 2′, 4′-BNA/LNA-7-deazaguanine (LNA-
7cG) and 2′, 4′-BNA/LNA-8-aza-7-deazaguanine (LNA-8n7cG), which avoid extra …

Synthesis of three different amide-linked LNA-type dinucleotides and their incorporation into
9-mer and 17-mer oligodeoxynucleotides is described; compared to the reference DNA …

Asymmetric synthesis of d-2′, 3′-dideoxy-2′, 3′-endo-methylene nucleosides was
achieved via the intermediate 2, 3-endo-methylene pentofuranoyl chloride 6, which was …

8-AMIN0(2-AMINOETHYL)-2’-DEOXYADENOSINE INCORPORATION INTO DNA BY SOLID
PHASE SYNTHESIS+ Page 1 hxqanic & Medicinal Chemistry Lemrs. Vol.3, No.4, pp. 689-692 …

The 2′-O, 3′-C-[(2 ″R)-2 ″-C-(acetoxymethyl) ethylene]-linked and 2′-O, 3′-C-[(2
″S)-2 ″-C-(acetoxymethyl) ethylene]-linked bicyclic thymine nucleosides 12R and 12S …

Abstract Oligonucleotides from 2′-deoxy-2′(S)-ethinyl-adenosine,-cytidine,-guanosine,-
thymidine and-uridine have been prepared. Whereas the modified pyrimidine …

In this study, 2′-O, 4′-C-methyleneoxy-bridged nucleic acid, a unique consecutive three-
acetal-containing nucleic acid (TaNA), was designed. Pyrimidine derivatives of methylated …

We have earlier reported the synthesis and antisense properties of the conformationally
constrained oxetane-C and-T containing oligonucleotides, which have shown effective down …