Conclusion: Our findings show that copy number loss of FHIT is associated with lymph node
metastasis (LNM) and suggest that the down-regulation of Fhit indicates poor prognosis in …

Abnormalities of FHIT, a candidate tumor suppressor gene located at 3p14. 2, have been
found frequently in multiple tumor types, including head and neck squamous cell carcinoma …

The tumor suppressor gene FHIT (fragile histidine triad) at chromosomal position 3p14. 2 is
altered by deletions in human tumors. The frequency and specificity of its inactivation vary …

The FHIT (fragile histidine triad) gene at chromosome 3p14. 2 spans the FRA3B fragile site
and encodes for a diadenosine triphosphate hydrolase-type protein. FHIT is frequently …

The FHIT gene is involved in the pathogenesis of many cancers. The aim of this study was to
investigate allelic imbalance (AI) pattern at FHIT locus and alteration of FHIT gene in …

Fhit expression is absent or reduced in a subset of primary head and neck cancer. - Abstract -
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Purpose: Abnormalities of FHIT, a candidate tumor suppressor gene, have frequently been
found in multiple malignancies, including head and neck squamous cell carcinoma …

Methods Expression of FHIT protein, and proliferating cell nuclear antigen (PCNA) was
detected by SP immunohistochemistry in 41 specimens of LSCC and their matched adjacent …

Genetic alterations at the FHIT (fragile histidine triad) tumor suppressor gene have been
found in various human cancers. We have made an attempt to find point mutations of this …

Objective To analyze the mutation and abnormal expression of the FHIT gene in human
hypopharyngeal carcinoma. Method Matched normal and cancerous tissues from 24 …