Paternal epigenetic influences on placental health and their impacts on offspring development and disease
SS Bhadsavle, MC Golding - Frontiers in Genetics, 2022 - frontiersin.org
Our efforts to understand the developmental origins of birth defects and disease have
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …
primarily focused on maternal exposures and intrauterine stressors. Recently, research into …
Sex-specific placental responses in fetal development
CS Rosenfeld - Endocrinology, 2015 - academic.oup.com
The placenta is an ephemeral but critical organ for the survival of all eutherian mammals
and marsupials. It is the primary messenger system between the mother and fetus, where …
and marsupials. It is the primary messenger system between the mother and fetus, where …
The dysfunctional placenta epigenome: causes and consequences
SA Lee, C Ding - Epigenomics, 2012 - Taylor & Francis
The placenta is a fetal–maternal endocrine organ responsible for ensuring proper fetal
development throughout pregnancy. Adverse insults to the intrauterine environment often …
development throughout pregnancy. Adverse insults to the intrauterine environment often …
[HTML][HTML] The placental exposome, placental epigenetic adaptations and lifelong cardio-metabolic health
The placental exposome represents the sum of all placental exposures, and through its
influence on placental function can affect an individual's susceptibility to cardio-metabolic …
influence on placental function can affect an individual's susceptibility to cardio-metabolic …
Placental origins of chronic disease
Epidemiological evidence links an individual's susceptibility to chronic disease in adult life to
events during their intrauterine phase of development. Biologically this should not be …
events during their intrauterine phase of development. Biologically this should not be …
Emerging evidence that the mammalian sperm epigenome serves as a template for embryo development
Although more studies are demonstrating that a father's environment can influence child
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
health and disease, the molecular mechanisms underlying non-genetic inheritance remain …
Brain and placental transcriptional responses as a readout of maternal and paternal preconception stress are fetal sex specific
Introduction Despite a wealth of epidemiological evidence that cumulative parental lifetime
stress experiences prior to conception are determinant of offspring developmental …
stress experiences prior to conception are determinant of offspring developmental …
Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism
Compelling epidemiological and animal experimental data demonstrate that
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …
cardiometabolic and neuropsychiatric diseases originate in a suboptimal intrauterine …
Placenta, evolution and lifelong health
The intrauterine environment has an important influence on lifelong health, and babies who
grew poorly in the womb are more likely to develop chronic diseases in later life. Placental …
grew poorly in the womb are more likely to develop chronic diseases in later life. Placental …
A paternal environmental legacy: evidence for epigenetic inheritance through the male germ line
Literature on maternal exposures and the risk of epigenetic changes or diseases in the
offspring is growing. Paternal contributions are often not considered. However, some animal …
offspring is growing. Paternal contributions are often not considered. However, some animal …