The transcriptional activity of androgen receptor (AR) is modulated by coregulators that have
a significant influence on a number of functional properties of AR, including the ligand …

The androgen receptor signaling axis plays an essential role in the development, function
and homeostasis of male urogenital structures including the prostate gland although the …

Prostate cancer (PCa) progression relies on androgen receptor (AR) action. Preventing AR's
ligand-activation is the frontline treatment for metastatic PCa. Androgen deprivation therapy …

The biological action of androgens is mediated through the androgen receptor (AR).
Androgen-bound AR functions as a transcription factor to regulate genes involved in an …

Androgens and androgen receptor (AR) signaling are necessary for prostate development
and homeostasis. AR signaling also drives the growth of nearly all prostate cancer cells. The …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Androgen receptor (AR)-mediated transcription is critical in almost all stages of prostate
cancer (PCa) growth and differentiation. This process involves a complex interplay of …

Androgen receptor (AR), a key nuclear transcription factor in the prostate gland, is
expressed in all histological types and stages of prostate cancer. The AR regulates …

Prostate cancer is the most frequently diagnosed non‐skin cancer and the third leading
cause of cancer mortality in men. In the initial stages, prostate cancer is dependent on …

The transcriptional programs regulated through the activity of the androgen receptor (AR)
modulate normal prostate development and the maintenance of prostatic functions at …