The recent increase of pertussis in young adults in Japan is hypothesized to be due in part
to waning protection from the acellular pertussis vaccine. While a booster immunization may …

In 2008, the number of pertussis cases increased substantially among Japanese
adolescents, despite high coverage with acellular pertussis vaccine (DTaP). This study …

The incidence of reported cases with pertussis has increased in young adults in Japan and
the lack of additional booster immunizations containing pertussis components is suspected …

The number of pertussis cases in Japan has decreased dramatically following the
nationwide use of an acellular pertussis vaccine combined with diphtheria-tetanus toxoids …

Background Recent studies worldwide have reported increasing numbers of adults
diagnosed with Bordetella pertussis despite receiving childhood vaccinations. This study …

Recent epidemiologic data have indicated that adults are the most important reservoir that
transmit pertussis to children. However, conventional whole cell pertussis vaccine is …

Background: Due to the resurgence of pertussis, many countries have revised the pertussis
immunization schedules and recommended booster doses of pertussis component vaccine …

Background: Real evaluation of any vaccine can only be done after the vaccine has been in
routine use for a substantially long period of time. In Japan, acellular pertussis vaccine was …

In Japan, the morbidity rate for pertussis per 100,000 population was 147.6 in 1950 when
whole cell pertussis vaccine was introduced but dropped to 0.2 in 1972 when routine …

Acellular pertussis diphtheria, tetanus vaccine (APDT) was licensed in 1981 in Japan. This
vaccine contains pertussis toxin (PT), filamentous hemagglutinin (FHA) and agglutinogen …