The sympathetic/parasympathetic imbalance in heart failure with reduced ejection fraction

JS Floras, P Ponikowski - European heart journal, 2015 - academic.oup.com
Cardiovascular autonomic imbalance, a cardinal phenotype of human heart failure, has
adverse implications for symptoms during wakefulness and sleep; for cardiac, renal, and …

Autonomic control of ventricular function in health and disease: current state of the art

VYH van Weperen, CM Ripplinger… - Clinical Autonomic …, 2023 - Springer
Purpose Cardiac autonomic dysfunction is one of the main pillars of cardiovascular
pathophysiology. The purpose of this review is to provide an overview of the current state of …

Parasympathetic withdrawal is an integral component of autonomic imbalance in congestive heart failure: demonstration in human subjects and verification in a paced …

PF Binkley, E Nunziata, GJ Haas, SD Nelson… - Journal of the American …, 1991 - Elsevier
Although enhanced sympathetic tone is a well recognized component of the autonomic
profile characteristic of congestive heart failure, the contribution of parasympathetic …

Sympathetic activation in congestive heart failure: an updated overview

G Grassi, F Quarti-Trevano, MD Esler - Heart Failure Reviews, 2021 - Springer
Conclusive evidence demonstrates that the sympathetic nervous system activation is a
hallmark of congestive heart failure. This has been shown via a variety of biochemical …

Sympathetic dysregulation in heart failure: mechanisms and therapy

AYL Mark - Clinical cardiology, 1995 - Wiley Online Library
Heart failure is accompanied by sympathetic overactivity, which contributes to the
pathophysiology and to poor prognosis. This paper reviews the mechanisms and potential …

Autonomic imbalance and immune activation in chronic heart failure–pathophysiological links

EA Jankowska, P Ponikowski, MF Piepoli… - Cardiovascular …, 2006 - academic.oup.com
Activation of the immune system and derangement of cardiorespiratory neural control are
established elements of the complex pathophysiology of chronic heart failure (CHF). The …

Sympathetic and baroreflex alterations in congestive heart failure with preserved, midrange and reduced ejection fraction

G Seravalle, F Quarti-Trevano, R Dell'Oro… - Journal of …, 2019 - journals.lww.com
Aim: Although abnormalities in reflex sympathetic neural function represent a hallmark of
heart failure, no information is available on the neuroadrenergic and baroreflex function in …

The sympathetic nervous system in heart failure: physiology, pathophysiology, and clinical implications

F Triposkiadis, G Karayannis, G Giamouzis… - Journal of the American …, 2009 - jacc.org
Heart failure is a syndrome characterized initially by left ventricular dysfunction that triggers
countermeasures aimed to restore cardiac output. These responses are compensatory at …

Sympathetic nervous system activation in human heart failure: clinical implications of an updated model

JS Floras - Journal of the American College of cardiology, 2009 - jacc.org
Disturbances in cardiovascular neural regulation, influencing both disease course and
survival, progress as heart failure worsens. Heart failure due to left ventricular systolic …

The sympathetic nervous system and heart failure

DY Zhang, AS Anderson - Cardiology clinics, 2014 - cardiology.theclinics.com
Heart failure (HF) is a syndrome characterized by upregulation of the sympathetic nervous
system and abnormal responsiveness of the parasympathetic nervous system. 1 Evidence …