MG53 regulates membrane budding and exocytosis in muscle cells
Membrane recycling and remodeling contribute to multiple cellular functions, including cell
fusion events during myogenesis. We have identified a tripartite motif (TRIM72) family …
fusion events during myogenesis. We have identified a tripartite motif (TRIM72) family …
Mitsugumin 53 (MG53) facilitates vesicle trafficking in striated muscle to contribute to cell membrane repair
N Weisleder, H Takeshima, J Ma - Communicative & integrative …, 2009 - Taylor & Francis
Repair of the plasma membrane following damage is an important aspect of normal cellular
physiology, and disruption of this process is observed in many pathologic states. In a recent …
physiology, and disruption of this process is observed in many pathologic states. In a recent …
MG53 nucleates assembly of cell membrane repair machinery
Dynamic membrane repair is essential not only for long-term maintenance of cellular
integrity but also for recovery from acute cell injury. While compromised membrane repair …
integrity but also for recovery from acute cell injury. While compromised membrane repair …
Membrane repair defects in muscular dystrophy are linked to altered interaction between MG53, caveolin-3, and dysferlin
Defective membrane repair can contribute to the progression of muscular dystrophy.
Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in …
Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in …
Recombinant MG53 protein modulates therapeutic cell membrane repair in treatment of muscular dystrophy
N Weisleder, N Takizawa, P Lin, X Wang… - Science translational …, 2012 - science.org
Mitsugumin 53 (MG53), a muscle-specific TRIM family protein, is an essential component of
the cell membrane repair machinery. Here, we examined the translational value of targeting …
the cell membrane repair machinery. Here, we examined the translational value of targeting …
TRIM32 regulates skeletal muscle stem cell differentiation and is necessary for normal adult muscle regeneration
S Nicklas, A Otto, X Wu, P Miller, S Stelzer, Y Wen… - PloS one, 2012 - journals.plos.org
Limb girdle muscular dystrophy type 2H (LGMD2H) is an inherited autosomal recessive
disease of skeletal muscle caused by a mutation in the TRIM32 gene. Currently its …
disease of skeletal muscle caused by a mutation in the TRIM32 gene. Currently its …
Enhancing muscle membrane repair by gene delivery of MG53 ameliorates muscular dystrophy and heart failure in δ-Sarcoglycan-deficient hamsters
Muscular dystrophies (MDs) are caused by genetic mutations in over 30 different genes,
many of which encode for proteins essential for the integrity of muscle cell structure and …
many of which encode for proteins essential for the integrity of muscle cell structure and …
Ubiquitylation by Trim32 causes coupled loss of desmin, Z-bands, and thin filaments in muscle atrophy
S Cohen, B Zhai, SP Gygi, AL Goldberg - Journal of Cell Biology, 2012 - rupress.org
During muscle atrophy, myofibrillar proteins are degraded in an ordered process in which
MuRF1 catalyzes ubiquitylation of thick filament components (Cohen et al. 2009. J. Cell Biol …
MuRF1 catalyzes ubiquitylation of thick filament components (Cohen et al. 2009. J. Cell Biol …
Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane
SH Park, J Han, BC Jeong, JH Song, SH Jang… - Nature Structural & …, 2023 - nature.com
Defects in plasma membrane repair can lead to muscle and heart diseases in humans.
Tripartite motif-containing protein (TRIM) 72 (mitsugumin 53; MG53) has been determined to …
Tripartite motif-containing protein (TRIM) 72 (mitsugumin 53; MG53) has been determined to …
Redox-dependent oligomerization through a leucine zipper motif is essential for MG53-mediated cell membrane repair
M Hwang, J Ko, N Weisleder… - American Journal of …, 2011 - journals.physiology.org
We recently discovered that MG53, a muscle-specific tripartite motif (TRIM) family protein,
functions as a sensor of oxidation to nucleate the assembly of cell membrane repair …
functions as a sensor of oxidation to nucleate the assembly of cell membrane repair …