Membrane recycling and remodeling contribute to multiple cellular functions, including cell
fusion events during myogenesis. We have identified a tripartite motif (TRIM72) family …

Repair of the plasma membrane following damage is an important aspect of normal cellular
physiology, and disruption of this process is observed in many pathologic states. In a recent …

Dynamic membrane repair is essential not only for long-term maintenance of cellular
integrity but also for recovery from acute cell injury. While compromised membrane repair …

Defective membrane repair can contribute to the progression of muscular dystrophy.
Although mutations in caveolin-3 (Cav3) and dysferlin are linked to muscular dystrophy in …

Mitsugumin 53 (MG53), a muscle-specific TRIM family protein, is an essential component of
the cell membrane repair machinery. Here, we examined the translational value of targeting …

Limb girdle muscular dystrophy type 2H (LGMD2H) is an inherited autosomal recessive
disease of skeletal muscle caused by a mutation in the TRIM32 gene. Currently its …

Muscular dystrophies (MDs) are caused by genetic mutations in over 30 different genes,
many of which encode for proteins essential for the integrity of muscle cell structure and …

During muscle atrophy, myofibrillar proteins are degraded in an ordered process in which
MuRF1 catalyzes ubiquitylation of thick filament components (Cohen et al. 2009. J. Cell Biol …

Defects in plasma membrane repair can lead to muscle and heart diseases in humans.
Tripartite motif-containing protein (TRIM) 72 (mitsugumin 53; MG53) has been determined to …

We recently discovered that MG53, a muscle-specific tripartite motif (TRIM) family protein,
functions as a sensor of oxidation to nucleate the assembly of cell membrane repair …