Association between HLA-DM and HLA-DR in vivo
F Sanderson, C Thomas, J Neefjes, J Trowsdale - Immunity, 1996 - cell.com
The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …
HLA-DM interactions with intermediates in HLA-DR maturation and a role for HLA-DM in stabilizing empty HLA-DR molecules
LK Denzin, C Hammond, P Cresswell - The Journal of experimental …, 1996 - rupress.org
Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …
expression accumulate class II molecules associated with residual invariant (I) chain …
Determination of the HLA-DM interaction site on HLA-DR molecules
Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …
Cutting Edge: HLA-DM–Mediated Peptide Exchange Functions Normally on MHC Class II–Peptide Complexes That Have Been Weakened by Elimination of a …
A Ferrante, J Gorski - The journal of immunology, 2010 - journals.aai.org
The mechanism by which HLA-DM (DM) promotes exchange of peptides bound to HLA-DR
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …
HLA-DO is a negative modulator of HLA-DM-mediated MHC class II peptide loading
SM Van Ham, EPM Tjin, BF Lillemeier, U Grüneberg… - Current biology, 1997 - cell.com
Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …
Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.
AB Vogt, H Kropshofer… - Proceedings of the …, 1996 - National Acad Sciences
The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has
recently been shown to play a central role in the class II-associated antigen presentation …
recently been shown to play a central role in the class II-associated antigen presentation …
Cutting edge: HLA-DM functions through a mechanism that does not require specific conserved hydrogen bonds in class II MHC-peptide complexes
Z Zhou, KA Callaway, DA Weber… - The Journal of …, 2009 - journals.aai.org
HLA-DM catalyzes peptide dissociation and exchange in class II MHC molecules through a
mechanism that has been proposed to involve the disruption of specific components of the …
mechanism that has been proposed to involve the disruption of specific components of the …
In vivo and in vitro formation and dissociation of HLA-DR complexes with invariant chain-derived peptides
RR Avva, P Cresswell - Immunity, 1994 - cell.com
HLA-DR molecules associated with class II—associated invariant chain peptides (CLIP) are
generated in vivo as an intermediate in class II maturation. Such complexes can be …
generated in vivo as an intermediate in class II maturation. Such complexes can be …
“Chemical analogues” of HLA-DM can induce a peptide-receptive state in HLA-DR molecules
V Marin-Esteban, K Falk, O Rötzschke - Journal of Biological Chemistry, 2004 - ASBMB
We had recently identified small molecular compounds that are able to accelerate the ligand
exchange reactions of HLA-DR molecules. Here we show that this acceleration is due to the …
exchange reactions of HLA-DR molecules. Here we show that this acceleration is due to the …
Editing of the HLA‐DR‐peptide repertoire by HLA‐DM.
H Kropshofer, AB Vogt, G Moldenhauer… - The EMBO …, 1996 - embopress.org
Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …