The exchange of HLA class II–associated invariant chain peptides (CLIP) for cognate
peptide is catalyzed by HLA-DM under acidic conditions in vitro by an unknown mechanism …

Major histocompatibility complex (MHC) class II–positive cell lines which lack HLA-DM
expression accumulate class II molecules associated with residual invariant (I) chain …

Abstract HLA-DM removes CLIP and other loosely bound peptides from MHC class II
molecules. The crystal structures of class II molecules and of HLA-DM have not permitted …

The mechanism by which HLA-DM (DM) promotes exchange of peptides bound to HLA-DR
(DR) is still unclear. We have shown that peptide interaction with DR1 can be considered a …

Background: Class II molecules of the major histocompatibility complex become loaded with
antigenic peptides after dissociation of invariant chainderived peptides (CLIP) from the …

The nonclassical major histocompatibility complex class II molecule HLA-DM (DM) has
recently been shown to play a central role in the class II-associated antigen presentation …

HLA-DM catalyzes peptide dissociation and exchange in class II MHC molecules through a
mechanism that has been proposed to involve the disruption of specific components of the …

HLA-DR molecules associated with class II—associated invariant chain peptides (CLIP) are
generated in vivo as an intermediate in class II maturation. Such complexes can be …

We had recently identified small molecular compounds that are able to accelerate the ligand
exchange reactions of HLA-DR molecules. Here we show that this acceleration is due to the …

Antigenic peptide loading of classical major histocompatibility complex (MHC) class II
molecules requires the exchange of the endogenous invariant chain fragment CLIP (class II …