Endothelin (ET)-1, an endothelium-derived vasoconstrictor and mitogen, acts as an
antiapoptotic factor against serum deprivation–induced apoptosis of endothelial cells and …

Abstract Endothelin (ET)-1 is an endothelium-derived vasoconstrictor as well as a mitogen.
We have recently described a novel role of ET-1 as a survival factor for rat endothelial cells …

An imbalance between proliferation and apoptosis is an important causal factor for disorders
involving abnormal cell accumulation. The role and mechanism of how G protein-coupled …

Apoptosis of cardiac myocytes is thought to be a feature of many pathological disorders,
including congestive heart failure (CHF) and ischemic heart disease (IHD). Because recent …

Abstract Endothelin-1 (ET-1), an endothelium-derived vasoactive peptide, functions as a
potent vasoconstrictor as well as mitogen. We show here a novel role for ET-1 as an …

Apoptosis is well documented to be a common feature of many pathological processes of
the heart. Exogenous endothelin-1 (ET-1) has been shown to be proapoptotic or …

Many vertebrate cells are resistant to apoptotic stimuli, whose variety and the mechanisms
involved are not fully understood. Endothelin-1 is an endothelium-derived vasoactive …

An imbalance between proliferation and apoptosis is an important causal factor for disorders
involving abnormal cell accumulation. Endothelin (ET)-1, a 21-amino-acid peptide with …

The process of angiogenesis plays an important role in many physiological and pathological
conditions. Inhibition of endothelial cell (EC) apoptosis providing EC survival is thought to be …

Endothelin (ET) has been shown to activate mitogen-activated protein kinase (MAPK).
However, it has been unclear which of the ET receptors is coupled to MAPK activation. In the …