White matter hyperintensities are an independent predictor of physical decline in community-dwelling older people

JJJ Zheng, K Delbaere, JCT Close, P Sachdev, W Wen… - Gerontology, 2012 - karger.com
Background: Ageing is associated with physical disability, but little is known about the
influence of white matter hyperintensities (WMHs) on physical function decline in older …

The association between white matter hyperintensity volume and cognitive/physical decline in older people with dementia: A one-year longitudinal study

R Hairu, JCT Close, SR Lord, K Delbaere… - Aging & Mental …, 2022 - Taylor & Francis
Objectives Understanding the relationship between white matter hyperintensities (WMHs)
and cognitive and physical decline in people with dementia will assist in determining …

Neuropathologic correlates of white matter hyperintensities in a community-based cohort of older adults

K Arfanakis, AM Evia, SE Leurgans… - Journal of …, 2020 - content.iospress.com
Background: The association of white matter hyperintensities (WMH) with age-related
vascular and neurodegenerative pathologies remains incompletely understood. Objective …

White matter hyperintensities across the adult lifespan: relation to age, Aβ load, and cognition

A Garnier-Crussard, S Bougacha, M Wirth… - Alzheimer's research & …, 2020 - Springer
Background White matter hyperintensities (WMH) are very frequent in older adults and
associated with worse cognitive performance. Little is known about the links between WMH …

Association of white matter hyperintensities with cognitive decline and neurodegeneration

TR Li, BL Li, XR Xu, J Zhong, TS Wang… - Frontiers in Aging …, 2024 - frontiersin.org
Background The relationship between white matter hyperintensities (WMH) and the core
features of Alzheimer's disease (AD) remains controversial. Further, due to the prevalence of …

White matter hyperintensities are associated with falls in older people with dementia

ME Taylor, SR Lord, K Delbaere, W Wen… - Brain imaging and …, 2019 - Springer
Abstract White Matter Hyperintensities (WMHs) are associated with impaired gait, balance
and cognition and increased fall risk in cognitively healthy older people. However, few …

Rapid buildup of brain white matter hyperintensities over 4 years linked to ambulatory blood pressure, mobility, cognition, and depression in old persons

L Wolfson, DB Wakefield, N Moscufo… - … Series A: Biomedical …, 2013 - academic.oup.com
Background. Brain white matter hyperintensities (WMH) are associated with functional
decline in older people. We performed a 4-year cohort study examining progression of …

The relationship between cortical thickness and white matter hyperintensities in mid to late life

J Jiménez-Balado, C Habeck, Y Stern, T Eich - Neurobiology of Aging, 2024 - Elsevier
White matter hyperintensities (WMH) are associated with cortical thinning. Although they are
primarily detected in older participants, these lesions can appear in younger and midlife …

[HTML][HTML] Regional tract-specific white matter hyperintensities are associated with patterns of aging-related brain atrophy via vascular risk factors, but also …

M Habes, G Erus, JB Toledo, N Bryan… - Alzheimer's & Dementia …, 2018 - Elsevier
Introduction We sought to investigate associations of regional white matter hyperintensities
(WMHs) within white matter (WM) tracts with cardiovascular risk and brain aging-related …

[HTML][HTML] White matter hyperintensity load is associated with premature brain aging

N Busby, S Newman-Norlund, S Sayers… - Aging (Albany …, 2022 - ncbi.nlm.nih.gov
Background: Brain age is an MRI-derived estimate of brain tissue loss that has a similar
pattern to aging-related atrophy. White matter hyperintensities (WMHs) are neuroimaging …