Influenza still represents a problematic disease, involving millions of people every year and
causing hundreds of thousands of deaths. Only a few drugs are clinically available. The …

S119 was a top hit from an ultrahigh throughput screen performed to identify novel inhibitors
of influenza virus replication. It showed a potent antiviral effect (50% inhibitory concentration …

There is an urgent need to identify efficient antiviral compounds to combat existing and
emerging RNA virus infections, particularly those related to seasonal and pandemic …

Introduction Both vaccines and antiviral drugs represent the mainstay for preventing and
treating influenza. However, approved M2 ion channel inhibitors, neuraminidase inhibitors …

Seasonal and pandemic influenza have caused high morbidity and mortality worldwide.
Recent emergence of influenza A H5N1 and H1N1 strains has heightened concern …

Flu is a respiratory disease caused by influenza viruses. The disease progression of the flu
can vary from a mild, self-recovering acute illness to a life-threatening disease in children …

The high genetic variability of influenza A viruses poses a continual challenge to seasonal
and pandemic vaccine development, leaving antiviral drugs as the first line of defense …

There is an urgent need to identify efficient antiviral compounds to combat existing and
emerging RNA virus infections, particularly those related to seasonal and pandemic …

Please cite this paper as: Wathen et al.(2012) Antivirals in seasonal and pandemic influenza—
future perspectives. Influenza and Other Respiratory Viruses 7 (Suppl. 1), 76–80. Antiviral …

The influenza pandemic is a major threat to human health, and highly aggressive strains
such as H1N1, H5N1 and H7N9 have emphasized the need for therapeutic strategies to …