[PDF][PDF] Anti‐influenza drug discovery: identification of an orally bioavailable quinoline derivative through activity‐and property‐guided lead optimization

JY Yeh, MS Coumar, HY Shiao, TJ Lin, YC Lee… - …, 2012 - researchgate.net
All commercial chemicals and solvents are reagent grade and were used without further
treatment unless otherwise noted. All reactions were carried out under an atmosphere of dry …

[HTML][HTML] Drugs for influenza treatment: is there significant news?

N Principi, B Camilloni, A Alunno, I Polinori… - Frontiers in …, 2019 - frontiersin.org
Vaccines remain the best measure to reduce total influenza burden. However, presently
available influenza vaccines have some limitations that cause a reduced efficacy compared …

[HTML][HTML] Identification of Novel and Efficacious Chemical Compounds that Disturb Influenza A Virus Entry in vitro

H Khalil, T El Malah, AIA El Maksoud… - Frontiers in cellular …, 2017 - frontiersin.org
Influenza A virus is a negative RNA stranded virus of the family Orthomyxoviridae, and
represents a major public health threat, compounding existing disease conditions. Influenza …

[HTML][HTML] Recent advances in application of computer-aided drug design in anti-influenza a virus drug discovery

D Yu, L Wang, Y Wang - International Journal of Molecular Sciences, 2022 - mdpi.com
Influenza A is an acute respiratory infectious disease caused by the influenza A virus, which
seriously threatens global human health and causes substantial economic losses every …

[PDF][PDF] Antiviral drugs for the control of pandemic influenza virus

RJ Sugrue, BH Tan, DSY Yeo… - ANNALS-ACADEMY OF …, 2008 - researchgate.net
In the advent of an influenza virus pandemic it is likely that the administration of antiviral
drugs will be an important first line of defence against the virus. The drugs currently in use …

[HTML][HTML] Identification of small molecule inhibitors for influenza a virus using in silico and in vitro approaches

JN Makau, K Watanabe, T Ishikawa, S Mizuta… - PLoS …, 2017 - journals.plos.org
Influenza viruses have acquired resistance to approved neuraminidase-targeting drugs,
increasing the need for new drug targets for the development of novel anti-influenza drugs …

Emerging antiviral strategies to interfere with influenza virus entry

E Vanderlinden, L Naesens - Medicinal research reviews, 2014 - Wiley Online Library
Influenza A and B viruses are highly contagious respiratory pathogens with a considerable
medical and socioeconomical burden and known pandemic potential. Current influenza …

Targeting cell signalling pathways to fight the flu: towards a paradigm change in anti-influenza therapy

S Ludwig - Journal of Antimicrobial Chemotherapy, 2009 - academic.oup.com
Influenza is still one of the major plagues worldwide with the potential to cause pandemics.
The increasing frequency of viral resistance to the four US Food and Drug Administration …

Natural products as promising therapeutics for treatment of influenza disease

M Sencanski, D Radosevic, V Perovic… - Current …, 2015 - ingentaconnect.com
The influenza virus represents a permanent global health threat because it circulates not
only within but also between numerous host populations, thereby frequently causing …

[HTML][HTML] Screening for anti-influenza virus compounds from traditional Mongolian medicine by GFP-based reporter virus

MS Nie, XH Li, S Zhang, DD Zeng, YR Cai… - Frontiers in Cellular …, 2024 - frontiersin.org
Introduction Screening for effective antiviral compounds from traditional Mongolian medicine
not only aids in the research of antiviral mechanisms of traditional medicines, but is also of …