Mechanotransduction in endothelial cell migration

S Li, NF Huang, S Hsu - Journal of cellular biochemistry, 2005 - Wiley Online Library
The migration of endothelial cells (ECs) plays an important role in vascular remodeling and
regeneration. EC migration can be regulated by different mechanisms such as chemotaxis …

Endothelial cell migration during angiogenesis

L Lamalice, F Le Boeuf, J Huot - Circulation research, 2007 - Am Heart Assoc
Endothelial cell migration is essential to angiogenesis. This motile process is directionally
regulated by chemotactic, haptotactic, and mechanotactic stimuli and further involves …

The role of the dynamics of focal adhesion kinase in the mechanotaxis of endothelial cells

S Li, P Butler, Y Wang, Y Hu, DC Han… - Proceedings of the …, 2002 - National Acad Sciences
The migration of vascular endothelial cells (ECs) is critical in vascular remodeling. We
showed that fluid shear stress enhanced EC migration in flow direction and called this …

Effects of shear stress on endothelial cell haptotaxis on micropatterned surfaces

S Hsu, R Thakar, D Liepmann, S Li - Biochemical and biophysical research …, 2005 - Elsevier
Endothelial cell (EC) migration plays a critical role in vascular remodeling. Here we
investigated the interactions between haptotaxis (induced by extracellular matrix gradient) …

Effects of flow patterns on endothelial cell migration into a zone of mechanical denudation

PP Hsu, S Li, YS Li, S Usami, A Ratcliffe… - Biochemical and …, 2001 - Elsevier
Vascular endothelial cells (ECs) in vivo are subject to different flow conditions due to the
variation in vessel geometry. The aim of this study is to elucidate the effects of different flow …

Shear Stress–Induced Endothelial Cell Migration Involves Integrin Signaling Via the Fibronectin Receptor Subunits α5 and β1

C Urbich, E Dernbach, A Reissner, M Vasa… - … , and vascular biology, 2002 - Am Heart Assoc
Endothelial cell (EC) migration is required for angiogenesis, neovascularization, and
reendothelialization. Integrins, known as αβ-heterodimeric cell-surface receptors, regulate …

Cell-stiffness-induced mechanosignaling–a key driver of leukocyte transendothelial migration

A Schaefer, PL Hordijk - Journal of cell science, 2015 - journals.biologists.com
The breaching of cellular and structural barriers by migrating cells is a driving factor in
development, inflammation and tumor cell metastasis. One of the most extensively studied …

[PDF][PDF] Flow mechanotransduction regulates traction forces, intercellular forces, and adherens junctions

LH Ting, JR Jahn, NJ Sniadecki - Biophysical Journal, 2012 - cell.com
Endothelial cells react to shear stresses with mechanotransduction responses that modify
the cytoskeleton and cell-cell contacts. Cultures of endothelial cells were patterned as …

Shear stress protects against endothelial regulation of vascular smooth muscle cell migration in a coculture system

HQ Wang, LX Huang, MJ Qu, ZQ Yan, B Liu… - Endothelium, 2006 - Taylor & Francis
Vascular endothelial cells (ECs) are constantly exposed to blood flow–induced shear stress;
these forces strongly influence the behaviors of neighboring vascular smooth muscle cells …

[HTML][HTML] Rho mediates the shear-enhancement of endothelial cell migration and traction force generation

YT Shiu, S Li, WA Marganski, S Usami, MA Schwartz… - Biophysical journal, 2004 - cell.com
The migration of vascular endothelial cells in vivo occurs in a fluid dynamic environment due
to blood flow, but the role of hemodynamic forces in cell migration is not yet completely …