Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease
AM Salazar, AM Leisgang, AA Ortiz, AS Murtishaw… - Neurobiology of …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive
decline of memory and cognitive function. The disease is characterized by the presence of …
decline of memory and cognitive function. The disease is characterized by the presence of …
Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model
S Krantic, N Isorce, N Mechawar… - Journal of …, 2012 - content.iospress.com
The relevance of-amino-butyric acid (GABA)-ergic dysfunctions in the pathology of
Alzheimer's disease (AD) remains a matter of debate. In the present study, we characterized …
Alzheimer's disease (AD) remains a matter of debate. In the present study, we characterized …
Amyloid-β, tau, and the cholinergic system in Alzheimer's disease: Seeking direction in a tangle of clues
A Majdi, S Sadigh-Eteghad… - Reviews in the …, 2020 - degruyter.com
The link between histopathological hallmarks of Alzheimer's disease (AD), ie amyloid
plaques, and neurofibrillary tangles, and AD-associated cognitive impairment, has long …
plaques, and neurofibrillary tangles, and AD-associated cognitive impairment, has long …
Recent update on the Alzheimer's disease progression, diagnosis and treatment approaches
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disorder,
manifested by the loss of memory and cognitive abilities, behavioral disturbance and …
manifested by the loss of memory and cognitive abilities, behavioral disturbance and …
[HTML][HTML] Neurotransmitters in prevention and treatment of Alzheimer's disease
Z Yang, Y Zou, L Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of cognitive impairment in middle-aged
and older populations. There is a lack of drugs that demonstrate significant efficacy in AD, so …
and older populations. There is a lack of drugs that demonstrate significant efficacy in AD, so …
Molecular mechanisms of emerging therapeutic targets in Alzheimer's disease: a systematic review
T Premkumar, S Sajitha Lulu - Neurochemical Journal, 2022 - Springer
Alzheimer's disease (AD) is a severe cognitive impairment considered to be the leading
cause of dementia worldwide. The pathophysiology includes extracellular accumulation of …
cause of dementia worldwide. The pathophysiology includes extracellular accumulation of …
Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging
M Iwakiri, K Mizukami, MD Ikonomovic, M Ishikawa… - Acta …, 2005 - Springer
Alterations in the γ-aminobutyric acid (GABA) neurotransmitter and receptor systems may
contribute to vulnerability of hippocampal pyramidal neurons in Alzheimer's disease (AD) …
contribute to vulnerability of hippocampal pyramidal neurons in Alzheimer's disease (AD) …
Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker
HIL Jacobs, J Radua, HC Lückmann… - … & Biobehavioral Reviews, 2013 - Elsevier
The increasing prevalence of Alzheimer's disease (AD) emphasizes the need for sensitive
biomarkers. Memory, a core deficit in AD, involves the interaction of distributed brain …
biomarkers. Memory, a core deficit in AD, involves the interaction of distributed brain …
[HTML][HTML] GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults
FC Quevenco, SJ Schreiner, MG Preti… - NeuroImage: Clinical, 2019 - Elsevier
Background Effects of beta-amyloid accumulation on neuronal function precede the clinical
manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain …
manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain …
The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease
Alzheimer's disease (AD) is the most common neurological disease, which is associated
with gradual memory loss and correlated with synaptic hyperactivity and abnormal …
with gradual memory loss and correlated with synaptic hyperactivity and abnormal …