Alterations of GABA B receptors in the APP/PS1 mouse model of Alzheimer's disease

AM Salazar, AM Leisgang, AA Ortiz, AS Murtishaw… - Neurobiology of …, 2021 - Elsevier
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by the progressive
decline of memory and cognitive function. The disease is characterized by the presence of …

Hippocampal GABAergic neurons are susceptible to amyloid-β toxicity in vitro and are decreased in number in the Alzheimer's disease TgCRND8 mouse model

S Krantic, N Isorce, N Mechawar… - Journal of …, 2012 - content.iospress.com
The relevance of-amino-butyric acid (GABA)-ergic dysfunctions in the pathology of
Alzheimer's disease (AD) remains a matter of debate. In the present study, we characterized …

Amyloid-β, tau, and the cholinergic system in Alzheimer's disease: Seeking direction in a tangle of clues

A Majdi, S Sadigh-Eteghad… - Reviews in the …, 2020 - degruyter.com
The link between histopathological hallmarks of Alzheimer's disease (AD), ie amyloid
plaques, and neurofibrillary tangles, and AD-associated cognitive impairment, has long …

Recent update on the Alzheimer's disease progression, diagnosis and treatment approaches

A Malaiya, M Singhai, M Singh, SK Prajapati… - Current Drug …, 2022 - ingentaconnect.com
Alzheimer's disease (AD) is a multifactorial, progressive, neurodegenerative disorder,
manifested by the loss of memory and cognitive abilities, behavioral disturbance and …

[HTML][HTML] Neurotransmitters in prevention and treatment of Alzheimer's disease

Z Yang, Y Zou, L Wang - International Journal of Molecular Sciences, 2023 - mdpi.com
Alzheimer's disease (AD) is the most frequent cause of cognitive impairment in middle-aged
and older populations. There is a lack of drugs that demonstrate significant efficacy in AD, so …

Molecular mechanisms of emerging therapeutic targets in Alzheimer's disease: a systematic review

T Premkumar, S Sajitha Lulu - Neurochemical Journal, 2022 - Springer
Alzheimer's disease (AD) is a severe cognitive impairment considered to be the leading
cause of dementia worldwide. The pathophysiology includes extracellular accumulation of …

Changes in hippocampal GABABR1 subunit expression in Alzheimer's patients: association with Braak staging

M Iwakiri, K Mizukami, MD Ikonomovic, M Ishikawa… - Acta …, 2005 - Springer
Alterations in the γ-aminobutyric acid (GABA) neurotransmitter and receptor systems may
contribute to vulnerability of hippocampal pyramidal neurons in Alzheimer's disease (AD) …

Meta-analysis of functional network alterations in Alzheimer's disease: toward a network biomarker

HIL Jacobs, J Radua, HC Lückmann… - … & Biobehavioral Reviews, 2013 - Elsevier
The increasing prevalence of Alzheimer's disease (AD) emphasizes the need for sensitive
biomarkers. Memory, a core deficit in AD, involves the interaction of distributed brain …

[HTML][HTML] GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

FC Quevenco, SJ Schreiner, MG Preti… - NeuroImage: Clinical, 2019 - Elsevier
Background Effects of beta-amyloid accumulation on neuronal function precede the clinical
manifestation of Alzheimer's disease (AD) by years and affect distinct cognitive brain …

The fate of interneurons, GABAA receptor sub‐types and perineuronal nets in Alzheimer's disease

AB Ali, A Islam, A Constanti - Brain Pathology, 2023 - Wiley Online Library
Alzheimer's disease (AD) is the most common neurological disease, which is associated
with gradual memory loss and correlated with synaptic hyperactivity and abnormal …