Objective. To assess the effect of B cell depletion therapy on effector CD4+ T cell
homeostasis and its relation to objective measures of disease activity in patients with …

Since B-cell hyperactivity and pathologic antibody response are key features in the
immunopathogenesis of primary Sjögren's syndrome (pSS), the role of follicular T helper …

Objective To assess the phenotype of reconstituting B cells after B cell depletion, and to
assess the effect of reconstitution on the balance of Treg cells and effector T cells in patients …

INTRODUCTION Primary Sjögren syndrome (pSS) is a systemic autoimmune disease,
characterised by an infiltration of the exocrine glands, leading to sicca syndrome …

Follicular T helper (Tfh) cells have a crucial role in regulating immune responses within
secondary lymphoid follicles by directing B cell differentiation towards memory B cells and …

Objective To assess the effect of abatacept (CTLA‐4Ig), which limits T cell activation, on
homeostasis of CD4+ T cell subsets and T cell–dependent B cell hyperactivity in patients …

A histologic hallmark of primary SS (pSS) is lymphocytic infiltration of the salivary and
lacrimal glands, in particular by CD4+ T and B cells. In the early stages of the disease …

The aim of this study was to investigate the possible role of follicular helper T (TFH) cells in
the pathogenesis of primary Sjögren's syndrome (pSS) by analyzing immune-competent …

Since primary Sjögren's syndrome (pSS) is an autoummune disease of B cell hyperactivity
and pathologic autoantibody response, follicular helper T (Tfh) cells and follicular regulatory …

Abstract Background Primary Sjögren's syndrome (pSS) is a common chronic autoimmune
disease characterized by lymphocytic infiltration of salivary and lacrimal glands. The current …