Background Integration of human immunodeficiency virus type 1 (HIV-1) into a host cell
chromosome is an essential step under the control of the viral integrase (IN). Although this …

Background Persistence of latent, replication-competent provirus is the main impediment
towards the cure of HIV infection. One of the critical questions concerning HIV latency is the …

LEDGF/p75 can tether over-expressed lentiviral integrase proteins to chromatin but how this
underlies its integration cofactor role for these retroviruses is unclear. While a single …

LEDGF/p75 is a chromatin-interacting, cellular cofactor of HIV integrase that dictates
lentiviral integration site preference. In this study we determined the role of the PWWP …

Retroviral replication hinges on the formation of the provirus, the integrated product of the
linear DNA that is made during reverse transcription. Integration is catalyzed by the viral …

HIV DNA integration is favored in active genes, but the underlying mechanism is unclear.
Cellular lens epithelium-derived growth factor (LEDGF/p75) binds both chromosomal DNA …

Recently, a new class of HIV-1 integrase (IN) inhibitors with a dual mode of action, called IN-
LEDGF/p75 allosteric inhibitors (INLAIs), was described. Designed to interfere with the IN …

To achieve productive infection, the reverse transcribed cDNA of human immunodeficiency
virus type 1 (HIV-1) is inserted in the host cell genome. The main protein responsible for this …

We have reported that human immunodeficiency virus type 1 (HIV-1) integrase (IN) forms a
specific nuclear complex with human lens epithelium-derived growth factor/transcription co …

Human lens epithelium-derived growth factor (LEDGF)/p75 protein forms a specific nuclear
complex with human immunodeficiency virus type 1 (HIV-1) integrase and is essential for …