Brain injury in the premature infant is a problem of enormous importance. Periventricular
leukomalacia (PVL) is the major neuropathologic form of this brain injury and underlies most …

Major advances in understanding the cellular mechanisms of brain injury have presented a
host of potential targets for intervention. This is particularly true of hypoxic-ischemic injury …

Although periventricular white matter injury is a leading cause of major neurologic disability
in premature infants, the relationship between myelination deficiency and long-term …

Although periventricular white matter injury (PWMI) is the leading cause of chronic
neurological disability and cerebral palsy in survivors of premature birth, the cellular …

Intrauterine infection and inflammation are major reasons for preterm birth. The switch from
placenta-mediated to lung-mediated oxygen supply during birth is associated with a sudden …

Cerebral white matter injury, characterised by loss of premyelinating oligodendrocytes (pre-
OLs), is the most common form of injury to the preterm brain and is associated with a high …

Immature oligodendrocytes (OLs) derive from a large pool of late OL progenitors that
populate human cerebral white matter throughout the latter half of gestation. We recently …

Hypoxic–ischemic brain injury in premature infants results in cerebral white matter lesions
with prominent oligodendroglial injury and loss, a disorder termed periventricular …

Distinctive cerebral lesions with disruptions to the developing white matter are found in very
low birth weight (VLBW) infants. Although hypoxia-ischemia (HI) is a causal pathway, the …

Reactive nitrogen species are thought to be involved in both hypoxic‐ischemic and cytokine‐
induced brain injury, including periventricular leukomalacia (PVL), the major pathological …