The transcription factor NF-κB has been well recognized as a pivotal regulator of
inflammation in rheumatoid arthritis (RA), but recent developments revealed a broad …

The family of nuclear factor-kappaB (NF-κB) transcription factors is intimately involved in the
regulation of expression of numerous genes in the setting of the inflammatory response …

The nuclear factor-κB (NF-κB) family of transcription factors is essential for the expression of
pro-inflammatory cytokines, but can also induce regulatory pathways. NF-κB can be …

The transcription factor NF-κB is a pivotal regulator of inflammatory responses. While the
activation of NF-κB in the arthritic joint has been associated with rheumatoid arthritis (RA), its …

Inflammatory arthritis is associated with devastating joint tissue destruction and periarticular
bone erosion. Although secreted products of infiltrating immune cells perpetuate the …

Nuclear factor-kappaB (NF-κB) proteins constitute a family of transcription factors that are
stimulated by pro-inflammatory cytokines, chemokines, stress-related factors and …

In the synovial cells of patients with RA, activation of the nuclear factor-κB (NF-κB) pathway
results in the transactivation of a multitude of responsive genes that contribute to the …

The transcription factor NF-κB plays crucial roles in the regulation of inflammation and
mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune …

Objective. To examine whether nuclear factor κB (NF‐κB) is activated in cultured synovial
cells in response to tumor necrosis factor α (TNFα) and to investigate the correlation …

The transcription factor NF-κB might be the Holy Grail of therapeutic targets for rheumatoid
arthritis (RA). It serves as a “master switch” for an inflammatory cascade that encompasses …