Cell signaling pathways often crosstalk generating complex biological behaviors observed
in different cellular contexts. Frequently, laboratory experiments focus on a few putative …

The biomolecules inside or near cells form a complex interacting system. Cellular
phenotypes and behaviors arise from the totality of interactions among the components of …

Signal transduction allows a cell to communicate with its surroundings. Many diseases such
as developmental disorders, autoimmunity, and cancer have been shown to arise from …

Understanding signal transduction in cellular systems is a central issue in systems biology.
Numerous experiments from different laboratories generate an abundance of individual …

Mathematical modeling of biological processes provides deep insights into complex cellular
systems. While quantitative and continuous models such as differential equations have been …

Boolean network models are one of the simplest models to study complex dynamic behavior
in biological systems. They can be applied to unravel the mechanisms regulating the …

The number of mathematical models for biological pathways is rapidly growing. In particular,
Boolean modelling proved to be suited to describe large cellular signalling networks …

Background The understanding of regulatory and signaling networks has long been a core
objective in Systems Biology. Knowledge about these networks is mainly of qualitative …

Modern life sciences research increasingly relies on computational solutions, from large
scale data analyses to theoretical modeling. Within the theoretical models Boolean networks …

Molecular mechanisms of health and disease are often represented as systems biology
diagrams, and the coverage of such representation constantly increases. These static …