The effect of a bacteriophage on diversification of the opportunistic bacterial pathogen, Pseudomonas aeruginosa

MA Brockhurst, A Buckling… - Proceedings of the …, 2005 - royalsocietypublishing.org
Pseudomonas aeruginosa is an opportunistic human pathogen that colonizes the lungs of
cystic fibrosis (CF) patients. CF lungs often contain a diverse range of P. aeruginosa …

Polylysogeny magnifies competitiveness of a bacterial pathogen in vivo

N Burns, CE James, E Harrison - Evolutionary applications, 2015 - Wiley Online Library
The rise of next generation sequencing is revealing a hidden diversity of temperate phages
within the microbial community. While a handful of these phages have been well …

Cystic Fibrosis-Niche Adaptation of Pseudomonas aeruginosa Reduces Virulence in Multiple Infection Hosts

NI Lorè, C Cigana, I De Fino, C Riva, M Juhas… - PloS one, 2012 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa is able to thrive in diverse ecological
niches and to cause serious human infection. P. aeruginosa environmental strains are …

Evolutionary diversification of Pseudomonas aeruginosa in an artificial sputum model

EV Davies, CE James, MA Brockhurst, C Winstanley - BMC microbiology, 2017 - Springer
Background During chronic lung infections of cystic fibrosis patients Pseudomonas
aeruginosa populations undergo extensive evolutionary diversification. However, the …

Rapid diversification of Pseudomonas aeruginosa in cystic fibrosis lung-like conditions

A Schick, R Kassen - … of the National Academy of Sciences, 2018 - National Acad Sciences
Chronic infection of the cystic fibrosis (CF) airway by the opportunistic pathogen
Pseudomonas aeruginosa is the leading cause of morbidity and mortality for adult CF …

Temperate phages both mediate and drive adaptive evolution in pathogen biofilms

EV Davies, CE James, D Williams… - Proceedings of the …, 2016 - National Acad Sciences
Temperate phages drive genomic diversification in bacterial pathogens. Phage-derived
sequences are more common in pathogenic than nonpathogenic taxa and are associated …

The role of multispecies social interactions in shaping Pseudomonas aeruginosa pathogenicity in the cystic fibrosis lung

S O'Brien, JL Fothergill - FEMS microbiology letters, 2017 - academic.oup.com
Pseudomonas aeruginosa is a major pathogen in the lungs of cystic fibrosis (CF) patients.
However, it is now recognised that a diverse microbial community exists in the airways …

Characterization of JG024, a Pseudomonas aeruginosa PB1-like broad host range phage under simulated infection conditions

J Garbe, A Wesche, B Bunk, M Kazmierczak… - BMC microbiology, 2010 - Springer
Background Pseudomonas aeruginosa causes lung infections in patients suffering from the
genetic disorder Cystic Fibrosis (CF). Once a chronic lung infection is established, P …

Phenotypic Heterogeneity of Pseudomonas aeruginosa Populations in a Cystic Fibrosis Patient

ML Workentine, CD Sibley, B Glezerson, S Purighalla… - PloS one, 2013 - journals.plos.org
The opportunistic pathogen Pseudomonas aeruginosa chronically infects the lower airways
of patients with cystic fibrosis. Throughout the course of infection this organism undergoes …

Molecular Epidemiology and Dynamics of Pseudomonas aeruginosa Populations in Lungs of Cystic Fibrosis Patients

L Jelsbak, HK Johansen, AL Frost… - Infection and …, 2007 - Am Soc Microbiol
The ability to establish lifelong persistent infections is a fundamental aspect of the
interactions between many pathogenic microorganisms and their mammalian hosts. One …