Pregabalin is a new synthetic molecule and a structural derivative of the inhibitory
neurotransmitter γ-aminobutyric acid. It is an α 2-δ (α 2-δ) ligand that has analgesic …

OBJECTIVE To review pregabalin's pharmacology, pharmacokinetics, efficacy, and adverse
effects in the treatment of neuropathic pain, epilepsy, and anxiety. DATA SOURCES A …

Pregabalin, a compound with a novel mechanism of action (MOA), has demonstrated
efficacy as an adjunctive treatment for epilepsy and in several neuropathic pain models …

BACKGROUND:: The US Food and Drug Administration (FDA) approved pregabalin in
December 2004 for the treatment of neuropathic pain associated with diabetic peripheral …

Pregabalin (S-[+]-3-isobutylgaba) was designed as a lipophilic GABA (γ-aminobutyric acid)
analogue substituted at the 3′-position in order to facilitate diffusion across the blood–brain …

Used mainly for the management of neuropathic pain, pregabalin is a gabapentinoid or
anticonvulsant that was initially developed as an antiepileptic agent. After more than a …

Pregabalin is an antagonist of voltage gated Ca2+ channels and specifically binds to alpha-
2-delta subunit to produce antiepileptic and analgesic actions. It successfully alleviates the …

OBJECTIVE:: This article reviews the available information on pregabalin, a new
anticonvulsant for peripheral neuropathic pain. Pregabalin was provisionally approved by …

Pregabalin (Lyrica, Pfizer) is a GABA analog with similar structure and actions to
gabapentin. It has antiepileptic, analgesic and anxiolytic activity. Pregabalin is indicated for …

Pfizer is developing pregabalin, a follow-up compound to its GABA agonist gabapentin, for
the potential treatment of several central nervous system (CNS) disorders including …