Cigarette smoke (CS) is the major cause of chronic obstructive pulmonary disease (COPD).
Interleukin-17A (IL-17A) is a pivotal cytokine that regulates lung immunity and inflammation …

It is now established that an excessive and sustained mobilisation of neutrophils is a
hallmark of several chronic inflammatory lung disorders, including severe obstructive lung …

Background: Recent reports have suggested an involvement of neutrophilic inflammation
driven by interleukin (IL)-17 from Th17 cells, especially in severe, refractory asthma. It …

Increasing evidence suggests that asthma is a heterogeneous disorder regulated by distinct
molecular mechanisms. In a cross-sectional study of asthmatics of varying severity (n= 51) …

Chronic obstructive pulmonary disease (COPD) is a worldwide threat. Cigarette smoke (CS)
exposure causes cardiopulmonary disease and COPD and increases the risk for pulmonary …

The Th2 cytokine IL-13 regulates several aspects of the asthmatic phenotype, including
airway inflammation, airway hyperresponsiveness, and mucus production. The Th17 …

Pulmonary infection is a leading cause of hospitalization in world. Lung damage due to
infection and host mediated pathology can have life threatening consequences. Factors that …

Abstract Interleukin (IL)-17A, IL-22 and IL-10 have been implicated in the development of
chronic obstructive pulmonary disease (COPD), but their expression in COPD is uncertain …

The proinflammatory cytokine interleukin (IL)-18 was originally discovered as an interferon-γ-
inducing factor in 1995. IL-18 is known to play an important role in Th1/Tc1 polarization and …

Airway remodeling is a frequent pathological feature of severe asthma leading to permanent
airway obstruction in up to 50% of cases and to respiratory disability. Although structural …