The BRAF oncogene is mutated in 15% of sporadic colorectal cancers. Approximately half of
these BRAF mutant cancers demonstrate frequent frameshift mutations termed microsatellite …

BACKGROUND Alterations of BRAF have been implicated in the carcinogenesis of
colorectal tumors with microsatellite instability (MSI). These alterations were attributed to …

The BRAF (V600E) mutation in colorectal cancers that are microsatellite stable (MSS)
confers a poor patient prognosis, whereas BRAF mutant microsatellite-unstable (MSI) …

Background & Aims: Recently, an alternative pathway of tumorigenesis has been identified
in the colorectum associated with serrated precursor lesions, variable levels of microsatellite …

Background BRAF is a member of RAF family of serine/threonine kinases and mediates
cellular responses to growth signals through the RAS-RAF-MAP kinase pathway. Activating …

Abstract Background and Aims Between 10 and 15% of all cases of colorectal cancer are
the result of microsatellite instability (MSI) in the genetic pathway due to an alteration in the …

Purpose: The BRAF gene encodes a serine/threonine kinase and plays an important role in
the mitogen-activated protein kinase signaling pathway. BRAF mutations in sporadic …

The majority of “serrated pathway” colorectal cancers have mutation of the BRAF oncogene
and display the CpG island methylator phenotype (CIMP). Half these cancers have …

Activating mutations of BRAF have been frequently observed in microsatellite unstable
(MSI+) colorectal carcinomas (CRCs), in which mutations of BRAF and KRAS are mutually …

Purpose The prognostic significance of biomarkers in colorectal cancer is still being defined.
This study aimed to determine the prognostic significance of BRAF mutation alone and in …