The origin and pathophysiological background of multiple sclerosis (MS)-associated fatigue
is poorly understood. There is no unifying concept of its nature and its determinants to date …

Background Cognitive impairment in individuals with Multiple Sclerosis (iwMS) is
traditionally diagnosed using performance measures on cognitive tests. Yet, performance on …

Background and Purpose. Fatigue and memory impairment are common symptoms in
multiple sclerosis (MS) and both may interact with cognition. This can contribute to making a …

Objective Cognitive fatigue (CF) can be defined as decreased performance with sustained
cognitive effort. The present study examined the interrelatedness of disease severity, fatigue …

Objective: To investigate the influence of disability and the speed of disability accumulation
on fatigue and depression in a large cohort of patients with multiple sclerosis (MS). Methods …

We determined biopsychosocial correlates of general, physical, and mental fatigue in MS
patients, by evaluating the additional contribution of potentially modifiable factors after …

Fatigue in Multiple Sclerosis (MS) is one of the most debilitating symptoms in patients with
Multiple Sclerosis (pwMS). It interferes significantly with career as well as participation in …

Background: Among patients with multiple sclerosis (MS), fatigue is the most commonly
reported symptom. It can be subdivided into an effort-dependent (fatigability) and an effort …

This study examined whether an alteration in the effort–reward relationship, a theoretical
framework based on cognitive neuroscience, could explain cognitive fatigue. Forty persons …

Fatigue is an overwhelming sense of tiredness or lack of energy, affecting both mental and
physical domains. Fatigue is reported by about 50% of patients with multiple sclerosis (MS) …