Background Recent advances in proteomics technologies such as two-hybrid, phage
display and mass spectrometry have enabled us to create a detailed map of biomolecular …

Multiprotein complexes play central roles in many cellular pathways. Although many high-
throughput experimental techniques have already enabled systematic screening of pairwise …

Background Protein interactions are crucial components of all cellular processes. Recently,
high-throughput methods have been developed to obtain a global description of the …

Datasets obtained by large-scale, high-throughput methods for detecting protein–protein
interactions typically suffer from a relatively high level of noise. We describe a novel method …

Background Most proteins form macromolecular complexes to perform their biological
functions. However, experimentally determined protein complex data, especially of those …

Background After complete sequencing of a number of genomes the focus has now turned
to proteomics. Advanced proteomics technologies such as two-hybrid assay, mass …

We introduce clustering with overlapping neighborhood expansion (ClusterONE), a method
for detecting potentially overlapping protein complexes from protein-protein interaction data …

Motivation: Protein complexes are important for understanding principles of cellular
organization and function. High-throughput experimental techniques have produced a large …

Motivation: High-throughput protein interaction detection methods are strongly affected by
false positive and false negative results. Focused experiments are needed to complement …

Background Identification of protein complexes is crucial for understanding principles of
cellular organization and functions. As the size of protein-protein interaction set increases, a …