Impact of maternal circulating cholesterol and gestational diabetes mellitus on lipid metabolism in human term placenta

C Marseille‐Tremblay… - Molecular …, 2008 - Wiley Online Library
Maternal hypercholesterolemia (HC) during pregnancy and gestational diabetes mellitus
(GDM) are associated with disturbance of fetal development which may also modify key …

Effect of an enriched cholesterol diet during gestation on fatty acid synthase, HMG-CoA reductase and SREBP-1/2 expressions in rabbits

C Marseille-Tremblay, A Gravel, J Lafond, C Mounier - Life Sciences, 2007 - Elsevier
Pregnancy is associated with hyperlipidemia and hypercholesterolemia in humans. These
changes take place to support fetal growth and development, and modifications of these …

Modulation of cholesterol transport by insulin-treated gestational diabetes mellitus in human full-term placenta

E Dubé, M Ethier-Chiasson, J Lafond - Biology of reproduction, 2013 - academic.oup.com
Gestational diabetes mellitus (GDM) is a common complication of pregnancy that is
characterized by glucose intolerance, leads to dyslipidemia, and is aggravated by obesity …

The effect of high glucose on lipid metabolism in the human placenta

CH Hulme, A Nicolaou, SA Murphy, AEP Heazell… - Scientific reports, 2019 - nature.com
Diabetes mellitus (DM) during pregnancy can result in fetal overgrowth, likely due to
placental dysfunction, which has health consequences for the infant. Here we test our …

Placental accumulation of triacylglycerols in gestational diabetes mellitus and its association with altered fetal growth are related to the differential expressions of …

M Balachandiran, Z Bobby, G Dorairajan… - Experimental and …, 2021 - thieme-connect.com
Introduction Gestational diabetes mellitus (GDM) exhibit altered placental lipid metabolism.
The molecular basis of this altered metabolism is not clear. Altered placental expression of …

Placental lipid transport and content in response to maternal overweight and gestational diabetes mellitus in human term placenta

L Song, N Wang, Y Peng, B Sun, W Cui - Nutrition, Metabolism and …, 2022 - Elsevier
Background and aims Placental lipid transport is altered in women with high prepregnancy
body mass index (pre-BMI) or gestational diabetes (GDM), which consequently affects foetal …

Modulation of cholesterol transport by maternal hypercholesterolemia in human full-term placenta

R Zhang, S Dong, W Ma, X Cai, Z Le, R Xiao, Q Zhou… - PloS one, 2017 - journals.plos.org
The significance of maternal cholesterol transporting to the fetus under normal as well as
pathological circumstances is less understood. The objective of this study was to observe …

Maternal hypercholesterolemia during pregnancy: potential modulation of cholesterol transport through the human placenta and lipoprotein profile in maternal and …

C Cantin, B Fuenzalida, A Leiva - Placenta, 2020 - Elsevier
During pregnancy, there is a progressive increase in the levels of maternal cholesterol, a
lipid that is essential for foetal growth and development. This increase can occur in a …

Maternal-fetal cholesterol transfer in human term pregnancies

H Horne, AM Holme, MCP Roland, MB Holm… - Placenta, 2019 - Elsevier
Objectives The extent to which the human term fetus utilizes cholesterol released from the
placenta has remained elusive. Our aims were to estimate the net mass of cholesterol taken …

BMI-independent effects of gestational diabetes on human placenta

L Stirm, M Kovářová, S Perschbacher… - The Journal of …, 2018 - academic.oup.com
Purpose Recently, alterations in maternal lipid metabolism were associated with gestational
diabetes mellitus (GDM). However, detailed plasma lipid profiles and their relevance for …