Confinement controlled mineralization of calcium carbonate within collagen fibrils

H Ping, H Xie, Y Wan, Z Zhang, J Zhang… - Journal of materials …, 2016 - pubs.rsc.org
Confinement is common in biological systems and plays a critical role in the structure-
forming process of biominerals. However, the knowledge of confinement effects on …

The synergic role of collagen and citrate in stabilizing amorphous calcium phosphate precursors with platy morphology

JM Delgado-López, F Bertolotti, J Lyngsø, JS Pedersen… - Acta biomaterialia, 2017 - Elsevier
Bioinspired in vitro collagen mineralization experiments have been performed in the
presence of citrate and the combined role of the two bone organic matrix components in …

Growth of mineralized collagen films by oriented calcium fluoride nanocrystal assembly with enhanced cell proliferation

W Fang, H Ping, Y Huang, H Xie, H Wang… - Journal of Materials …, 2021 - pubs.rsc.org
Bone is a highly calcified tissue with 60 wt% inorganic components. It is made up of
mineralized collagen fibrils, where the platelet-like hydroxyapatite nanocrystals deposit …

Protein-free formation of bone-like apatite: New insights into the key role of carbonation

AC Deymier, AK Nair, B Depalle, Z Qin, K Arcot… - Biomaterials, 2017 - Elsevier
The nanometer-sized plate-like morphology of bone mineral is necessary for proper bone
mechanics and physiology. However, mechanisms regulating the morphology of these …

Tailoring calcite growth through an amorphous precursor in a hydrogel environment

JA Lopez-Berganza, S Chen… - Crystal Growth & …, 2019 - ACS Publications
The precipitation of calcium carbonate in hydrogel-like environments is used by certain
living organisms to build functional mineral–organic composite structures. Here, we …

Citrate improves collagen mineralization via interface wetting: a physicochemical understanding of biomineralization control

C Shao, R Zhao, S Jiang, S Yao, Z Wu, B Jin… - Advanced …, 2018 - Wiley Online Library
Biological hard tissues such as bones always contain extremely high levels of citrate, which
is believed to play an important role in bone formation as well as in osteoporosis treatments …

Toward the understanding of small protein-mediated collagen intrafibrillar mineralization

Z Wang, P Ustriyana, K Chen, W Zhao… - ACS Biomaterials …, 2020 - ACS Publications
The design of improved materials for orthopedic implants and bone tissue engineering
scaffolds relies on materials mimicking the properties of bone. Calcium phosphate (Ca-PO4) …

[HTML][HTML] Role of carboxylic organic molecules in interfibrillar collagen mineralization

A Indurkar, R Choudhary, K Rubenis… - … in Bioengineering and …, 2023 - frontiersin.org
Bone is a composite material made up of inorganic and organic counterparts. Most of the
inorganic counterpart accounts for calcium phosphate (CaP) whereas the major organic part …

Oriented calcite micropillars and prisms formed through aggregation and recrystallization of poly (acrylic acid) stabilized nanoparticles

X Long, Y Ma, KR Cho, D Li, JJ De Yoreo… - Crystal growth & …, 2013 - ACS Publications
Though calcium carbonate crystals with various morphologies have been successfully
fabricated via bioinspired methods, the mechanism underlying crystallization of one …

In Situ Evaluation of Calcium Phosphate Nucleation Kinetics and Pathways during Intra- and Extrafibrillar Mineralization of Collagen Matrices

D Kim, B Lee, S Thomopoulos, YS Jun - Crystal growth & design, 2016 - ACS Publications
We revealed that nucleation sites within collagen fibrils determined pathways for calcium
phosphate (CaP) nucleation and its transformation, from amorphous species to crystalline …