[HTML][HTML] Reprogramming of tumor-associated macrophages with anticancer therapies: radiotherapy versus chemo-and immunotherapies
Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis,
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …
[HTML][HTML] Targeting tumor-associated macrophages in anti-cancer therapies: convincing the traitors to do the right thing
In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …
[HTML][HTML] Proton irradiation orchestrates macrophage reprogramming through NFκB signaling
Tumor-associated macrophages (TAMs) represent potential targets for anticancer treatments
as these cells play critical roles in tumor progression and frequently antagonize the …
as these cells play critical roles in tumor progression and frequently antagonize the …
[HTML][HTML] The effects of radiation therapy on the macrophage response in cancer
The efficacy of radiotherapy, a mainstay of cancer treatment, is strongly influenced by both
cellular and non-cellular features of the tumor microenvironment (TME). Tumor-associated …
cellular and non-cellular features of the tumor microenvironment (TME). Tumor-associated …
[HTML][HTML] Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy
In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …
[HTML][HTML] Current strategies to target tumor-associated-macrophages to improve anti-tumor immune responses
Established evidence demonstrates that tumor-infiltrating myeloid cells promote rather than
stop-cancer progression. Tumor-associated macrophages (TAMs) are abundantly present at …
stop-cancer progression. Tumor-associated macrophages (TAMs) are abundantly present at …
Targeting macrophages: therapeutic approaches in cancer
L Cassetta, JW Pollard - Nature reviews Drug discovery, 2018 - nature.com
Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …
[HTML][HTML] Understanding the origin and diversity of macrophages to tailor their targeting in solid cancers
Tumor-associated macrophages (TAMs) are a major component of the tumor immune
microenvironment (TIME) and are associated with a poor prognostic factor in several …
microenvironment (TIME) and are associated with a poor prognostic factor in several …
Therapeutic manipulation of tumor-associated macrophages: facts and hopes from a clinical and translational perspective
The stroma of most solid tumors is populated by myeloid cells, which mostly represent
macrophages. Tumor-associated macrophages (TAMs), strongly influenced by cancer cell …
macrophages. Tumor-associated macrophages (TAMs), strongly influenced by cancer cell …
Molecular pathways: deciphering mechanisms of resistance to macrophage-targeted therapies
DF Quail, JA Joyce - Clinical Cancer Research, 2017 - AACR
Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor
types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions …
types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions …