[HTML][HTML] Reprogramming of tumor-associated macrophages with anticancer therapies: radiotherapy versus chemo-and immunotherapies

G Genard, S Lucas, C Michiels - Frontiers in immunology, 2017 - frontiersin.org
Tumor-associated macrophages (TAMs) play a central role in tumor progression, metastasis,
and recurrence after treatment. Macrophage plasticity and diversity allow their classification …

[HTML][HTML] Targeting tumor-associated macrophages in anti-cancer therapies: convincing the traitors to do the right thing

C Belgiovine, E Digifico, C Anfray, A Ummarino… - Journal of Clinical …, 2020 - mdpi.com
In the last decade, it has been well-established that tumor-infiltrating myeloid cells fuel not
only the process of carcinogenesis through cancer-related inflammation mechanisms, but …

[HTML][HTML] Proton irradiation orchestrates macrophage reprogramming through NFκB signaling

G Genard, AC Wera, C Huart, B Le Calve… - Cell death & …, 2018 - nature.com
Tumor-associated macrophages (TAMs) represent potential targets for anticancer treatments
as these cells play critical roles in tumor progression and frequently antagonize the …

[HTML][HTML] The effects of radiation therapy on the macrophage response in cancer

C Beach, D MacLean, D Majorova, JN Arnold… - Frontiers in …, 2022 - frontiersin.org
The efficacy of radiotherapy, a mainstay of cancer treatment, is strongly influenced by both
cellular and non-cellular features of the tumor microenvironment (TME). Tumor-associated …

[HTML][HTML] Reprogramming tumor-associated macrophages as a unique approach to target tumor immunotherapy

SU Khan, MU Khan, M Azhar Ud Din, IM Khan… - Frontiers in …, 2023 - frontiersin.org
In the last ten years, it has become increasingly clear that tumor-infiltrating myeloid cells
drive not just carcinogenesis via cancer-related inflammatory processes, but also tumor …

[HTML][HTML] Current strategies to target tumor-associated-macrophages to improve anti-tumor immune responses

C Anfray, A Ummarino, F Torres Andon, P Allavena - Cells, 2019 - mdpi.com
Established evidence demonstrates that tumor-infiltrating myeloid cells promote rather than
stop-cancer progression. Tumor-associated macrophages (TAMs) are abundantly present at …

Targeting macrophages: therapeutic approaches in cancer

L Cassetta, JW Pollard - Nature reviews Drug discovery, 2018 - nature.com
Infiltration of macrophages in solid tumours is associated with poor prognosis and correlates
with chemotherapy resistance in most cancers. In mouse models of cancer, macrophages …

[HTML][HTML] Understanding the origin and diversity of macrophages to tailor their targeting in solid cancers

K Kielbassa, S Vegna, C Ramirez, L Akkari - Frontiers in immunology, 2019 - frontiersin.org
Tumor-associated macrophages (TAMs) are a major component of the tumor immune
microenvironment (TIME) and are associated with a poor prognostic factor in several …

Therapeutic manipulation of tumor-associated macrophages: facts and hopes from a clinical and translational perspective

P Allavena, C Anfray, A Ummarino, FT Andón - Clinical Cancer Research, 2021 - AACR
The stroma of most solid tumors is populated by myeloid cells, which mostly represent
macrophages. Tumor-associated macrophages (TAMs), strongly influenced by cancer cell …

Molecular pathways: deciphering mechanisms of resistance to macrophage-targeted therapies

DF Quail, JA Joyce - Clinical Cancer Research, 2017 - AACR
Tumor-associated macrophages (TAMs) are a major cellular component of numerous tumor
types. TAM-targeted therapies include depletion strategies, inhibiting their effector functions …