[HTML][HTML] Molecular alterations in relation to histopathological characteristics in a large series of pediatric papillary thyroid carcinoma from a single institution

E Macerola, A Proietti, AM Poma, C Ugolini… - Cancers, 2021 - mdpi.com
Simple Summary Papillary thyroid carcinoma (PTC) in pediatric patients shows different
characteristics compared with PTC in adults. In this large mono-institutional cohort of …

RET, NTRK, ALK, BRAF, and MET Fusions in a Large Cohort of Pediatric Papillary Thyroid Carcinomas

B Pekova, V Sykorova, S Dvorakova, E Vaclavikova… - Thyroid, 2020 - liebertpub.com
Background: Pediatric papillary thyroid carcinoma (PTC) is a rare malignancy, but with
increasing incidence. Pediatric PTCs have distinct clinical and pathological features and …

Fusion oncogenes are the main genetic events found in sporadic papillary thyroid carcinomas from children

MICV Cordioli, L Moraes, AU Bastos, P Besson… - Thyroid, 2017 - liebertpub.com
Background: Previous studies reported significant differences in the clinical presentation
and outcomes of papillary thyroid carcinoma (PTC) in pediatric patients compared with …

Unique molecular signatures are associated with aggressive histology in pediatric differentiated thyroid cancer

KP Mollen, AD Shaffer, L Yip, SE Monaco, P Huyett… - Thyroid, 2022 - liebertpub.com
Background: Molecular testing (MT) enhances the diagnostic accuracy of thyroid fine-needle
aspiration biopsy, reducing the need for diagnostic lobectomy in adult patients with …

[HTML][HTML] A Multifocal Pediatric Papillary Thyroid Carcinoma (PTC) Harboring the AGK-BRAF and RET/PTC3 Fusion in a Mutually Exclusive Pattern Reveals Distinct …

L Sisdelli, MIV Cordioli, F Vaisman, O Monte… - Biology, 2021 - mdpi.com
Simple Summary Genetic alterations, such as RET/PTC and AGK-BRAF fusions, are
frequent events in pediatric papillary thyroid carcinoma (PTC). However, their role as …

Classic architecture with multicentricity and local recurrence, and absence of TERT promoter mutations are correlates of BRAF V600E harboring pediatric papillary …

S Onder, S Ozturk Sari, G Yegen, IC Sormaz… - Endocrine …, 2016 - Springer
This study is aimed to investigate the BRAF V600E and TERT promoter mutation profile of
50 pediatric papillary thyroid carcinomas (PTCs) to refine their clinicopathological correlates …

[HTML][HTML] Major oncogenic drivers and their clinicopathological correlations in sporadic childhood papillary thyroid carcinoma in Belarus

TI Rogounovitch, SV Mankovskaya, MV Fridman… - Cancers, 2021 - mdpi.com
Simple Summary Childhood papillary thyroid carcinomas (PTCs) detected after the
Chernobyl accident were genetically characterized by a high prevalence of gene …

Single point mutations in pediatric differentiated thyroid cancer

AS Alzahrani, AK Murugan, E Qasem, M Alswailem… - Thyroid, 2017 - liebertpub.com
Purpose: Differentiated thyroid cancer (DTC) is rare in children. Previous studies have
suggested that it has different clinicopathologic features and mutation profiles compared …

NTRK fusion oncogenes in pediatric papillary thyroid carcinoma in northeast United States

ML Prasad, M Vyas, MJ Horne, RK Virk, R Morotti… - Cancer, 2016 - Wiley Online Library
BACKGROUND An increase in thyroid cancers, predominantly papillary thyroid carcinoma
(PTC), has been recently reported in children. METHODS The histopathology of 28 …

[HTML][HTML] Mutational analysis using next generation sequencing in pediatric thyroid cancer reveals BRAF and fusion oncogenes are common

RS Newfield, W Jiang, DX Sugganth… - International Journal of …, 2022 - Elsevier
Background We previously described mutation rates of BRAF V600E, RAS, RET-PTC and
PAX8-PPARγ in pediatric subjects with well-differentiated thyroid cancer (WDTC). We …