The theory of Darwinian evolution describes the origin of biological information. As Oparin
stated in 1924, an evolving system (ie, an information-gaining system) is generally able to …

Long before science began, the question of the origin of life was answered by religion and
mythology. With the work of Lamarck and Darwin, science started to try to give new answers …

Minimal self-replicating systems typically consist of three components: a product molecule,
and two substrate molecules that become joined to form another product molecule. An …

Chemical systems capable of templating and catalyzing their own synthesis—known as
replicating systems—have started to appear in the chemical literature over the last 25 years …

Self-replication involves the product-directed assembly of components to form a new
product; in its simplest form, it involves the joining of just two components. The product acts …

The relevance of autocatalysis to the molecular origins of biological metabolism is discussed
as well as important considerations for the design of 'self-replicating'molecules. Typically …

The first non-enzymatic self-replicating systems, as proposed by von Kiedrowski (Angew
Chem Int Ed Engl 25 (10): 932–935, 1986) and Orgel (Nature 327 (6120): 346–347, 1987) …

This dissertation is focused on two major investigations. The first one is about the
mechanism with which a known self-replicator can create copies of itself. This study led to …

How does it work? It involves product-directed assembly of components to form a new
product. The simplest selfreplicating system entails the joining of only two components (see …

Over the past twenty years molecules capable of templating their own synthesis, so called
self–replicating molecules have gained prominence in the literature. We show herein that …