Self-replication is the de facto hallmark of life and has thus far eluded efforts to mimic it in
physical engineered systems. According to the John von Neumann self-replication model …

Molecular biology has brought a wealth of information in support of Darwin's theory of
natural selection. Investigations of the cellular machinery have supplied striking evidence for …

In this chapter, we focus on emergent catalysis by supramolecular self‐replicators. Coupling
of catalysis and replication represents an important advance in the fields of supramolecular …

The biggest challenge for origin-of-life scientists is to account for the first self-replicating
molecule. Genes are needed to make proteins and proteins are needed to make genes, so …

All known organisms rely on DNA as the genetic material and proteins as the chief agent of
function, but the machinery needed to copy DNA and express proteins is far too complex to …

The RNA world hypothesis suggests that RNA molecules were generated from prebiotic
components enabling the generation of early life forms. The catalytic and informational …

One process that chemists have aimed to incorporate into artificial systems is self-
replication.[1] Synthetic self-replicating systems use self-assembly or molecular recognition …

A formidable synthetic apparatus for the creation of nanoscale molecular structures and
supramolecular assemblies through molecular structures can potentially be created from …

The conditions that led to the formation of the first organisms and the ways that life originates
from a lifeless chemical soup are poorly understood. The recent hypothesis of “RNA-peptide …

This thesis describes our attempts to develop new self-replicating systems and to install
functions that are as lifelike as possible. The introduction (chapter 1) opens with a general …